N-TERT-BUTYL-ALPHA-PHENYLNITRONE
- CAS No.
- 3376-24-7
- Chemical Name:
- N-TERT-BUTYL-ALPHA-PHENYLNITRONE
- Synonyms
- PBN;N-tert-Butyl-α-phenylnitrone;N-tert-Butyl-α-phenylnitrone;2-PropanaMine, 2-Methyl-N-(phenylMethylene)-, N-oxide;Butylphenylnitrone;Phenyl N-t-butylnitrone;PHENYL-TERT-BUTYLNITRONE;N-T-BUTYL-A-PHENYLNITRONE;PHENYL N-TERT-BUTYLNITRONE;c-phenyl-n-tert-butylnitrone
- CBNumber:
- CB8469861
- Molecular Formula:
- C11H15NO
- Molecular Weight:
- 177.24
- MDL Number:
- MFCD00008799
- MOL File:
- 3376-24-7.mol
Melting point | 73-74 °C(lit.) |
---|---|
Boiling point | 283℃ |
Density | 0.990 |
refractive index | 1.5480 (estimate) |
Flash point | 119℃ |
storage temp. | Store at <= 20°C. |
solubility | DMSO: soluble |
form | powder |
pka | 1.50±0.53(Predicted) |
color | white |
Water Solubility | Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml). |
Merck | 14,7056 |
BRN | 2044028 |
CAS DataBase Reference | 3376-24-7(CAS DataBase Reference) |
FDA UNII | 3I91332OPG |
EPA Substance Registry System | 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide (3376-24-7) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | TX1760000 | |||||||||
F | 10 | |||||||||
TSCA | Yes | |||||||||
HS Code | 2929 90 00 | |||||||||
NFPA 704 |
|
N-TERT-BUTYL-ALPHA-PHENYLNITRONE price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 80126 | N-tert-Butyl-α-phenylnitrone for ESR-spectroscopy | 3376-24-7 | 1g | $281 | 2024-03-01 | Buy |
Sigma-Aldrich | 8.41179 | N-tert-Butyl-α-phenylnitrone for synthesis | 3376-24-7 | 1g | $132 | 2024-03-01 | Buy |
Sigma-Aldrich | 203995 | N-tert-Butyl-α-phenylnitrone Most commonly-used free radical trap. | 3376-24-7 | 500mg | $111 | 2024-03-01 | Buy |
TCI Chemical | B1701 | N-tert-Butyl-alpha-phenylnitrone >98.0%(HPLC)(T) | 3376-24-7 | 1g | $68 | 2024-03-01 | Buy |
TCI Chemical | B1701 | N-tert-Butyl-alpha-phenylnitrone >98.0%(HPLC)(T) | 3376-24-7 | 5g | $218 | 2024-03-01 | Buy |
N-TERT-BUTYL-ALPHA-PHENYLNITRONE Chemical Properties,Uses,Production
Chemical Properties
white to light beige fine crystalline powder
Uses
N-tert-Butyl-α-phenylnitrone has been used:
- as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
- as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
- to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)
Uses
Spin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals.
Uses
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Synthesis Reference(s)
Tetrahedron, 48, p. 8677, 1992 DOI: 10.1016/S0040-4020(01)89443-6
General Description
Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
Biochem/physiol Actions
Product does not compete with ATP.
Purification Methods
Crystallise PBN from hexane. It is a free radical trap. [cf Janzen Methods Enzymology 105 188 1984, Beilstein 7 IV 519.]
N-TERT-BUTYL-ALPHA-PHENYLNITRONE Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3957 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7192 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8836 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34571 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
View Lastest Price from N-TERT-BUTYL-ALPHA-PHENYLNITRONE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-27 | N-tert-Butyl-α-phenylnitrone
3376-24-7
|
US $79.00-519.00 / g | 5g | 0.97 | 25kg | Shanghai UCHEM Inc. | ||
2024-07-20 | N-TERT-BUTYL-ALPHA-PHENYLNITRONE
3376-24-7
|
US $1.00 / Kg | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | ||
2019-07-06 | 3376-24-7
3376-24-7
|
US $1.00 / KG | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
- N-tert-Butyl-α-phenylnitrone
3376-24-7
- US $79.00-519.00 / g
- 0.97
- Shanghai UCHEM Inc.
- N-TERT-BUTYL-ALPHA-PHENYLNITRONE
3376-24-7
- US $1.00 / Kg
- 98%
- Shaanxi Dideu Medichem Co. Ltd
- 3376-24-7
3376-24-7
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
N-TERT-BUTYL-ALPHA-PHENYLNITRONE Spectrum
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