Histrelin
- CAS No.
- 76712-82-8
- Chemical Name:
- Histrelin
- Synonyms
- histrelin acetate;PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET;1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-;N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly;orf17070;Supprelin;RWJ-17070;HISTRELIN;Amyridine;Histreline Acetate
- CBNumber:
- CB8480046
- Molecular Formula:
- C66H86N18O12
- Molecular Weight:
- 1323.53
- MDL Number:
- MFCD00133494
- MOL File:
- 76712-82-8.mol
| alpha | D20 -33.9° (c = 1 in acetic acid) |
|---|---|
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 9.82±0.15(Predicted) |
| Stability | Hygroscopic |
| NCI Dictionary of Cancer Terms | histrelin acetate |
| FDA UNII | H50H3S3W74 |
| NCI Drug Dictionary | histrelin acetate |
| ATC code | L02AE05 |
| Proposition 65 List | Histrelin Acetate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360 |
| Precautionary statements | P201-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 60 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | OK6370800 |
| HS Code | 3504009000 |
| Hazardous Substances Data | 76712-82-8(Hazardous Substances Data) |
Histrelin price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L2761 | [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder | 76712-82-8 | 0.5mg | $158 | 2024-03-01 | Buy |
| Sigma-Aldrich | L2761 | [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder | 76712-82-8 | 1mg | $271 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0002921 | HISTRELIN 95.00% | 76712-82-8 | 1MG | $645.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb372383 | Histrelin Acetate > 95% | 76712-82-8 | 1mg | $691.9 | 2021-12-16 | Buy |
| Apolloscientific | BITH3026 | Histrelin | 76712-82-8 | 25mg | $719 | 2021-12-16 | Buy |
Histrelin Chemical Properties,Uses,Production
Description
Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.
Originator
Johnson & Johnson (U.S.A.)
Uses
[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide has been used:
- for inducing Batrachoseps gravid females to oviposit
- for comparing the effect of LHRH (luteinizing hormone-releasing hormone) agonists and dopamine antagonists in Lithobates pipiens
- for inducing oviposition in females of Taricha granulosa and Ensatina eschscoltzii
- to induce spawning in Spea hammondii adults
Uses
LHRH agonist.
Definition
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
brand name
Supprelin (Roberts Pharmaceutical).
Biochem/physiol Actions
Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu-Arg-Pro-NHEt ([des-Gly10, D-His(Bzl)6]-LH-RH) is a GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children. It inhibits actions of sex steroids on the male and female reproductive organs.
Histrelin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 995 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12832 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
View Lastest Price from Histrelin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-10 | Histrelin Acetate
76712-82-8
|
US $0.00 / g | 1g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-03-08 | Histrelin
76712-82-8
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd | |
 |
2023-05-20 | Histrelin
76712-82-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |
-
- Histrelin Acetate
76712-82-8
- US $0.00 / g
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Histrelin
76712-82-8
- US $10.00 / kg
- 99%
- Nantong Guangyuan Chemicl Co,Ltd
-
- Histrelin
76712-82-8
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd