AMINOPENTAMIDE SULFATE (200 MG)
- CAS No.
- 60-46-8
- Chemical Name:
- AMINOPENTAMIDE SULFATE (200 MG)
- Synonyms
- BL-139;Centrine;dimevamide;Valeramide-OM;Aminopentamide;RSYYDimevamide;Aminopentamid Sulfate;Methadone Impurity 28;AMINOPENTAMIDE SULFATE;AMINOPENTAMIDE SULFATE (200 MG)
- CBNumber:
- CB8501624
- Molecular Formula:
- C19H24N2O
- Molecular Weight:
- 296.41
- MDL Number:
- MFCD00865194
- MOL File:
- 60-46-8.mol
- MSDS File:
- SDS
| Melting point | 178-179℃ |
|---|---|
| Boiling point | 438°C (rough estimate) |
| Density | 1.069±0.06 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5600 (estimate) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 15.73±0.50(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| FDA UNII | IP1B47L61M |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
AMINOPENTAMIDE SULFATE (200 MG) Chemical Properties,Uses,Production
Originator
Centrine,Bristol,US,1953
Uses
Aminopentamide Sulfate affects gastric function and gastroduodenal ulcus. Used in the treatment of vomiting, diarrhea and other side effects in dogs/cats.
Definition
ChEBI: 4-(dimethylamino)-2,2-diphenylpentanamide is a diarylmethane.
Manufacturing Process
A mixture of 14 g (0.05 mol) of α,α-diphenyl-γ-dimethylaminovaleronitrile, 16
g (0.2 mol) of sodium acetate, 14 g (0.2 mol) of hydroxylamine hydrochloride
and 75 ml of ethyl alcohol was refluxed 18 hours. The mixture was cooled,
poured into water and neutralized with ammonium hydroxide. The heavy
white precipitate solidified on standing. The material was filtered and
recrystallized from isopropanol. After three recrystallizations the
aminopentamide product melted at 177° to 179°C.
The product is often used as the acid sulfate which is produced as follows:
252.0 g (0.85 mol) of α,α-diphenyl-γ-dimethylaminovaleronitrile was dissolved
in one liter of isopropanol, and 70 ml of concentrated sulfuric acid was added
as rapidly as possible. The mixture was heated until clear, then filtered and
diluted with 1,500 ml of anhydrous ethyl acetate. The solution was cooled and
filtered, and the white crystalline product was dried in vacuum over P2O5.
Therapeutic Function
Anticholinergic
Purification Methods
Crystallise dimevamide from aqueous EtOH. The hydrochloride forms leaflets from EtOH/Et2O with m 190-191o and is deliquescent. The picrate has m 210-211o. It is an antispasmotic. [Moffett et al. J Am Chem Soc 79 4451, 4457 1957, Beckett J Pharm Pharmacol 8 848 1956, Beilstein 14 III 1363, 14 IV 1865.]
AMINOPENTAMIDE SULFATE (200 MG) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7859 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15416 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10983 | 58 |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9300 | 58 |