4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
- CAS No.
- 749886-87-1
- Chemical Name:
- 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
- Synonyms
- JSH-23;CS-1344;JSH-23 HCL;JSH-23;JSH23;JSH 23;NF-κB Activation Inhibitor II;NFκB Activation Inhibitor II, JSH-23;4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE;4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine;JSH-23;JSH23;JSH 23;NF-ΚB ACTIVATION INHIBITOR II
- CBNumber:
- CB8649474
- Molecular Formula:
- C16H20N2
- Molecular Weight:
- 240.34
- MDL Number:
- MFCD09753595
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318-H400 | |||||||||
| Precautionary statements | P273-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-41-50/53 | |||||||||
| Safety Statements | 26-39-60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2921.59.8090 | |||||||||
| NFPA 704 |
|
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | J4455 | JSH-23 ≥98% (HPLC), solid | 749886-87-1 | 5mg | $176 | 2024-03-01 | Buy |
| TCI Chemical | M2734 | 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine >98.0%(GC) | 749886-87-1 | 25mg | $212 | 2022-04-27 | Buy |
| TCI Chemical | M2734 | 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine >98.0%(GC) | 749886-87-1 | 100mg | $464 | 2024-03-01 | Buy |
| Cayman Chemical | 15036 | JSH-23 ≥98% | 749886-87-1 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 15036 | JSH-23 ≥98% | 749886-87-1 | 5mg | $120 | 2024-03-01 | Buy |
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Chemical Properties,Uses,Production
Uses
A cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II, JSH-23
Uses
JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
Uses
JSH-23 is a cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II.
Definition
ChEBI: JSH-23 is a diamine that is 1,2-phenylenediamine carrying a methyl substituent at position 4 and a 3-phenylpropyl substituent at position N1. It has a role as a NF-kappaB inhibitor. It is a diamine and a substituted aniline. It is functionally related to a 1,2-phenylenediamine.
General Description
A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
Biological Activity
jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1].
Biochem/physiol Actions
Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
target
NF-κB
References
[1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4.
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24330 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
749886-87-1
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
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- 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
749886-87-1
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co