4-Acetoxy-2-azetidinone
- CAS No.
- 28562-53-0
- Chemical Name:
- 4-Acetoxy-2-azetidinone
- Synonyms
- 4-Oxo-2-azetidinyl acetate;4-ACETOXY-2-AZETIDINONE;3-Acetoxy-3-propanelactam;4-Acetyloxyazetidin-2-one;4-OXOAZETIDIN-2-YLACETATE;2-oxoazetidinium 4-acetate;2-Azetidinone, 4-(acetyloxy)-;4-ACETOXY-2-AZETIDINONE(4-AA);Acetic acid 4-oxo-2-azetidinyl ester;Acetic acid 2-oxoazetidin-4-yl ester
- CBNumber:
- CB8672313
- Molecular Formula:
- C5H7NO3
- Molecular Weight:
- 129.11
- MDL Number:
- MFCD00010593
- MOL File:
- 28562-53-0.mol
| Melting point | 38-40 °C (lit.) |
|---|---|
| Boiling point | 239.15°C (rough estimate) |
| Density | 1.3816 (rough estimate) |
| refractive index | 1.4220 (estimate) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | formic acid: soluble50mg/mL, clear, yellow-orange |
| pka | 13.41±0.40(Predicted) |
| BRN | 1524738 |
| CAS DataBase Reference | 28562-53-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Acetoxy-2-azetidinone(28562-53-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H334 |
| Precautionary statements | P260-P280-P284-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | C |
| Risk Statements | 34-43 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1759 8/PG 2 |
| WGK Germany | 3 |
| HazardClass | 8 |
| PackingGroup | III |
4-Acetoxy-2-azetidinone price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 272159 | 4-Acetoxy-2-azetidinone 98% | 28562-53-0 | 1g | $125 | 2023-01-07 | Buy |
| Sigma-Aldrich | 272159 | 4-Acetoxy-2-azetidinone 98% | 28562-53-0 | 5g | $300 | 2023-01-07 | Buy |
| TRC | A187958 | 4-Acetoxy-2-azetidinone | 28562-53-0 | 100mg | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA30790 | 4-Acetoxy-2-azetidinone | 28562-53-0 | 1g | $80 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | APN0000239 | 4-ACETOXY AZETIDIN-2-ONE 95.00% | 28562-53-0 | 1G | $155.4 | 2021-12-16 | Buy |
4-Acetoxy-2-azetidinone Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
4-Acetoxy-2-azetidinone was used in the synthesis of derivatized cyclopentenes in high regio- and diastereoselectivity. It was also used as a heterocyclic synthon for antibiotic and anti-inflammatory agents.
Synthesis Reference(s)
Journal of the American Chemical Society, 112, p. 7820, 1990 DOI: 10.1021/ja00177a067
Tetrahedron Letters, 29, p. 1409, 1988 DOI: 10.1016/S0040-4039(00)80310-X
Purification Methods
Dissolve it in CHCl3, dry (MgSO4) concentrate at 40o/70mm, or better at room temperature to avoid decomposition. Wash and stir the residual oil with hexane by decantation and discard the wash. Dry the oil at high vacuum when it should solidify, m 34o. It can be distilled at high vacuum, 80-82o/10-3mm, but this results in extensive losses. The purity can be checked by TLC using Merck Silica Gel F254 and eluting with EtOAc. The azetidinone has RF 0.38 (typical impurities have RF 0.67). The spots can be detected by the TDM spray. This is prepared from (A) 2.5g 4,4'-tetramethyldiaminodiphenylmethane (TDM) in 10mL AcOH and diluted with 50mL of H2O, (B) 5g KI in 100mL of H2O and (C) 0.3g ninhydrin in 10mL of AcOH and 90mL of H2O. The spray is prepared by mixing (A) and (B) with 1.5mL of (C) and stored in a brown bottle. [Clau et al. Justus Liebigs Ann Chem 539 1974, Michel et al. Org Synth 65 135 1987, Beilstein 21/12 V 4.]
4-Acetoxy-2-azetidinone Preparation Products And Raw materials
4-Acetoxy-2-azetidinone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34553 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9639 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from 4-Acetoxy-2-azetidinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-10-15 | 4-Acetoxy-2-azetidinone
28562-53-0
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-09-03 | 4-Acetoxy-2-azetidinone
28562-53-0
|
US $7.00 / KG | 1KG | 99% | JD 794 | Career Henan Chemical Co |
-
- 4-Acetoxy-2-azetidinone
28562-53-0
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-Acetoxy-2-azetidinone
28562-53-0
- US $7.00 / KG
- 99%
- Career Henan Chemical Co