6-Chlorooxindole
- CAS No.
- 56341-37-8
- Chemical Name:
- 6-Chlorooxindole
- Synonyms
- 6-chloroindolin-2-one;6-CHLORO-2-OXINDOLE;6-Chloro-2-oxoindole;AKOS 207-09;6-CHLOROOXINDOLE;6-CHLORO0XINDOLE;Isatin Impurity 18;6-Chlorooxindole,98%;6-Chlorooxindole 98%;6-Chlorooxindole >
- CBNumber:
- CB8681061
- Molecular Formula:
- C8H6ClNO
- Molecular Weight:
- 167.59
- MDL Number:
- MFCD00209962
- MOL File:
- 56341-37-8.mol
- MSDS File:
- SDS
| Melting point | 195-199 °C (lit.) |
|---|---|
| Boiling point | 329.0±42.0 °C(Predicted) |
| Density | 1.362±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Dimethylformamide |
| form | powder to crystal |
| pka | 13.39±0.20(Predicted) |
| color | Light yellow to Brown |
| InChI | InChI=1S/C8H6ClNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-2,4H,3H2,(H,10,11) |
| InChIKey | CENVPIZOTHULGJ-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC(Cl)=C2)CC1=O |
| CAS DataBase Reference | 56341-37-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-43-36/37/38 | |||||||||
| Safety Statements | 37/39-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29337900 | |||||||||
| NFPA 704 |
|
6-Chlorooxindole price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 636215 | 6-Chloro-2-oxindole 97% | 56341-37-8 | 5g | $23.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 636215 | 6-Chloro-2-oxindole 97% | 56341-37-8 | 25g | $42.7 | 2024-03-01 | Buy |
| TCI Chemical | C2024 | 6-Chlorooxindole >98.0%(GC) | 56341-37-8 | 5g | $32 | 2024-03-01 | Buy |
| TCI Chemical | C2024 | 6-Chlorooxindole >98.0%(GC) | 56341-37-8 | 25g | $95 | 2024-03-01 | Buy |
| Alfa Aesar | A19674 | 6-Chlorooxindole, 98% | 56341-37-8 | 5g | $40.65 | 2024-03-01 | Buy |
6-Chlorooxindole Chemical Properties,Uses,Production
Preparation
STEP A: 3-(2-nitro-4-chlorophenyl)pyruvic acid To a cooled mixture prepared by adding 13.6 g. of sodium to 300 ml. of ethanol is added a solution of 100 g. of 4-chloro-2-nitrotoluene and 84 g of diethyloxalate in 150 ml of ethanol while maintaining the temperature below 20℃. The resulting mixture is refluxed for one hour, cooled, 400 ml. of water added and the resulting mixture refluxed for 90 minutes. The ethanol is then evaporated to a small volume and the resulting precipi tate containstan and black material and the black mate rial is mechanically separated and discarded and the remainder (filtrate plus tan precipitate) used in the next step. STEP B: 4-chloro-2-nitro-phenylacetic acid The filtrate of Step A, above, is adjusted to pH 8-9 with 2 N sodium hydroxide and is heated at 35-40℃. while adding a 3-6% aqueous hydrogen peroxide solution until samples no longer turn dark on treatment with 2N sodium hydroxide. The tan precipitate is suspended in 1500 ml of water, adjusted to pH 8-9 and similarly treated with aqueous hydrogen peroxide. The combined reaction mixtures are then acidified with concentrated hydrochloride acid to obtain a precipitate which are re covered by filtration, washed 3 times with water and dried in vacuo. The crude product (mp 145-150° C) is recrystallized from ether to obtain 4-chloro-2-nitro phenylacetic acid, m.p. 156-159℃. STEP C: The product of Step B, above, is subjected to reductive cyclization analogously to Step B of Example 1 to obtain 6-chloro-oxindole, m.p. 185-189℃.
Chemical Properties
Off-white to tan crystalline powder
Uses
6-Chlorooxindole is a useful research chemical used in the design of potent non-peptide MDM2 inhibitors.
Definition
ChEBI: 6-Chlorooxindole is a member of indoles.
Application
6-chlorooxyindole, also known as 6-chloro-2-indolone, is an intermediate of Ziprasidone hydrochloride. Ziprasidone is an atypical broad-spectrum antipsychotic developed by Pfizer for the treatment of schizophrenia with a strong affinity for serotonin and dopamine receptor antagonists, particularly the 5-HTA2/DAD2 receptor.
6-Chlorooxindole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yongzeng Technology Co.,Ltd | +86-021-65281118 +86-13818947575 | sales@yongzchem.com | China | 137 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019 +86-15383190639 | admin@86-ss.com | China | 1000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
View Lastest Price from 6-Chlorooxindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | 6-Chlorooxindole
56341-37-8
|
US $999.00-800.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-04 | 6-Chlorooxindole
56341-37-8
|
US $0.00 / kg | 1kg | 98%min | 1000kgs | Shanghai Yongzeng Technology Co.,Ltd | |
 |
2024-09-24 | 6-Chlorooxindole
56341-37-8
|
US $0.00 / kg | 1kg | 97% | 500kg | Shanghai Joiny Pharmaceutical Co.,LTD |
-
- 6-Chlorooxindole
56341-37-8
- US $999.00-800.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 6-Chlorooxindole
56341-37-8
- US $0.00 / kg
- 98%min
- Shanghai Yongzeng Technology Co.,Ltd
-
- 6-Chlorooxindole
56341-37-8
- US $0.00 / kg
- 97%
- Shanghai Joiny Pharmaceutical Co.,LTD