Pirenzepine
- CAS No.
- 28797-61-7
- Chemical Name:
- Pirenzepine
- Synonyms
- LS-519-C12;pirenzepin;pirenzepine;Gastrozepin;nyl)acetyl)-;Tabe：Ulcuforton;PirenzepineBase;Pirenzepine dihydroc;Pirenzepine USP/EP/BP;Ombitasvir Impurity 2
- CBNumber:
- CB8694090
- Molecular Formula:
- C19H21N5O2
- Molecular Weight:
- 351.4
- MDL Number:
- MFCD00242717
- MOL File:
- 28797-61-7.mol
| Boiling point | 541.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.271±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | soluble in No data available |
| pka | 11.29±0.20(Predicted) |
| FDA UNII | 3G0285N20N |
| ATC code | A02BX03 |
Pirenzepine price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P508495 | Pirenzepine | 28797-61-7 | 500mg | $1260 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0006928 | PIRENZEPINE 95.00% | 28797-61-7 | 1G | $1529.85 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0006928 | PIRENZEPINE 95.00% | 28797-61-7 | 100MG | $605.17 | 2021-12-16 | Buy |
Pirenzepine Chemical Properties,Uses,Production
Description
Pirenzepine is available as dihydrochloride monohydrate, soluble in water. Because of its unfavorable balance between weak antisecretory and frequent anticholinergic adverse effects (dry mouth, blurred vision), pirenzepine is considered obsolete .
Chemical Properties
solid
Originator
Microsules Bernabo, Microsules Bernabo
Uses
antifungal
Uses
Pirenzepine, is an M1 selective antagonist, that is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm.
Definition
ChEBI: Pirenzepine is a pyridobenzodiazepine. It has a role as an anti-ulcer drug, a muscarinic antagonist and an antispasmodic drug.
Manufacturing Process
48.4 g of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo-diazepin-6-one were refluxed in 900 ml of absolute dioxane for 15 minutes. Thereafter, over a period of 45 minutes, 28 ml of chloroacetyl chloride and 52 ml of triethylamine were simultaneously added dropwise to the mixture. The mixture was refluxed for eight hours and then vacuum-filtered after having cooled. The filtrate was evaporated in vacuum. The crystalline residue was recrystallized from acetonitrile in the presence of activated charcoal. MP: 212°-213°C (with decomposition). Yield: 85% of theory.
A mixture of 67.5 g of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3b][1,4]benzodiazepin-6-one, 183 ml of N-methylpiperazine and 1.37 liters of absolute benzene was refluxed for 18 hours. Thereafter, the crystalline precipitate was vacuum filtered off, dissolved in aqueous 20% hydrochloric acid, the solution was evaporated in vacuum, the crystalline residue wasdissolved in 250 ml of water while heating, the solution was admixed with 150 ml of isopropanol and active charcoal, filtered, and 2.5 liters of isopropanol were added to the filtrate. After cooling, the precipitate was vacuum filtered off, yielding 70% of theory of the 5,11-dihydro-11-[(4'-methyl-1'-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride, M.P. 257259°C (decomp.).
The free base of pirenzepine, obtained from the dihydrochloride by making an aqueous solution thereof alkaline with dilute sodium hydroxide and extracting it with chloroform, had MP: 226°-228°C after recrystallization from methanol/ether.
Therapeutic Function
Antiulcer, Antiemetic
Biological Activity
M 1 muscarinic receptor selective antagonist. Inverse agonist activity reported.
Enzyme inhibitor
This hygroscopic antiulcerative (FWfree-base = 351.41 g/mol; CAS 28797-61- 7) is a gastric acid inhibitor and selective M1 muscarinic receptor antagonist, and the antisecretory properties of pirenzepine on gastric acid and pepsin secretion may be attributed to this antagonistic activity on muscarinic M1 receptors.
Pirenzepine Preparation Products And Raw materials
Raw materials
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Preparation Products
Pirenzepine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8840 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 990 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 | info@yuhaochemical.com | China | 9394 | 52 |
View Lastest Price from Pirenzepine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | Pirenzepine
28797-61-7
|
US $1.00 / KG | 1g | 85.0-99.8% | 20ton | Career Henan Chemical Co |
-
- Pirenzepine
28797-61-7
- US $1.00 / KG
- 85.0-99.8%
- Career Henan Chemical Co
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