1-Bromo-3-chloropropane

1-Bromo-3-chloropropane Properties

Melting point	-59 °C
Boiling point	144-145 °C (lit.)
Density	1.592 g/mL at 25 °C (lit.)
vapor pressure	7.5 hPa (20 °C)
refractive index	n20/D 1.486(lit.)
Flash point	81 °C
storage temp.	room temp
solubility	2.24g/l insoluble
form	liquid
color	Clear liquid
explosive limit	3.2-8.6%(V)
Water Solubility	insoluble
BRN	605278
Stability	Volatile
CAS DataBase Reference	109-70-6(CAS DataBase Reference)
FDA UNII	KA4WR2LS00
IARC	2B (Vol. 125)
NIST Chemistry Reference	Propane, 1-bromo-3-chloro-(109-70-6)
EPA Substance Registry System	Propane, 1-bromo-3-chloro- (109-70-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H302-H331-H335-H341-H350-H360FD-H412

Precautionary statements

P202-P261-P273-P301+P312-P304+P340+P311-P308+P313

Hazard Codes

Xn

Risk Statements

10-22-36/37/38-20/21/22-20/22-68-52/53-37

Safety Statements

16-45-36/37/39-26

RIDADR

UN 2688 6.1/PG 3

WGK Germany

3

RTECS

TX4113000

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29034980

Hazardous Substances Data

109-70-6(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 1100 - 1200 mg/kg LD50 dermal Rat > 2000 mg/kg

NFPA 704

	2
2		0

1-Bromo-3-chloropropane price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B62404	1-Bromo-3-chloropropane 99%	109-70-6	250g	$49	2024-03-01	Buy
Sigma-Aldrich	B62404	1-Bromo-3-chloropropane 99%	109-70-6	1kg	$134	2024-03-01	Buy
TCI Chemical	B0575	1-Bromo-3-chloropropane >99.0%(GC)	109-70-6	25g	$17	2024-03-01	Buy
TCI Chemical	B0575	1-Bromo-3-chloropropane >99.0%(GC)	109-70-6	500g	$53	2024-03-01	Buy
Alfa Aesar	A11395	1-Bromo-3-chloropropane, 99%	109-70-6	100g	$23.5	2024-03-01	Buy

Product number	Packaging	Price	Buy
B62404	250g	$49	Buy
B62404	1kg	$134	Buy
B0575	25g	$17	Buy
B0575	500g	$53	Buy
A11395	100g	$23.5	Buy

1-Bromo-3-chloropropane Chemical Properties,Uses,Production

Description

1-Bromo-3-chloropropane is a halogenated alkane compound containing one bromine atom and one chlorine atom in its structure. Due to the high electronegativity of halogens, the molecule of 1-Bromo-3-chloropropane is highly electrophilic and is easily attacked by electrophilic reagents such as nucleophilic reagents, Lewis acid, etc., which undergoes nucleophilic substitution reactions. The compound is relatively stable at room temperature, but is susceptible to elimination reactions at high temperatures or in the presence of strong acids or bases. In addition, prolonged exposure to air should be avoided because 1-Bromo-3-chloropropane molecules contain halogen atoms that are susceptible to reaction by oxygen and moisture in the air to produce products such as alcohols and aldehydes.

Chemical Properties

It is a clear and colorless liquid that is soluble in ethanol, ether, and chloroform but insoluble in water.

Uses

1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.

Definition

ChEBI: 1-Bromo-3-chloropropane (I-BCP or 109-70-6) is an organochlorine compound that can be used as a safer and equally effective alternative to chloroform. It serves as a phase-separation agent for the one-step method of RNA isolation from biological samples like animal and plant tissue. I-BCP can replace CHCl3 in RNA phase separations.

Preparation

The most common method for producing 1-Bromo-3-chloropropane is through the free-radical addition of anhydrous hydrogen bromide to allyl chloride. Alternatively, it can be prepared by reacting ethylene with methylene chlorobromide.

General Description

1-bromo-3-chloropropane appears as a colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Halogenated aliphatic compounds, such as 1-Bromo-3-chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Health Hazard

Inhalation of vapors or dust is extremely irritating. May cause burning of eyes and flow of tears. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Some of these materials may burn, but none ignite readily. Containers may explode when heated.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cland Br-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and BROMIDES.

Purification Methods

Wash it with conc H2SO4, water, 10% Na2CO3 solution, water again and then dry with CaCl2 and fractionally distil it just before use [Akagi et al. J Am Chem Soc 78 4034 1956]. [Beilstein 1 H 109, 1 IV 212.]

1-Bromo-3-chloropropane synthesis

Synthesis of 1-Bromo-3-chloropropane from Allyl chloride

1-Bromo-3-chloropropane Preparation Products And Raw materials

Raw materials

Benzoyl peroxide Hydrogen bromide Allyl chloride

Preparation Products

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Chlorpromazine hydrochloride 1,1-Cyclobutanedicarboxylic acid ACETOPHENAZINE MALEATE (200 MG) 5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile

Julolidine Oxatomide 3-ETHOXYCARBONYL-5,6-DIHYDRO-2-METHYL-4H-PYRAN LOMIFYLLINE Nefazodone

Cyclobutanemethanol Azetidine 4-Chlorobutyronitrile (Bromomethyl)cyclobutane 1-Bromo-5-hexanone

1-(3-(pyrrolidin-1-yl)propyl)hydrazine Pentoxifylline PERPHENAZINE Difenidol hydrochloride SEMOTIADIL

Azetidine hydrochloride Tirofiban (3-MORPHOLIN-4-YL-PROPYL)-HYDRAZINE 1-(3-Hydrazinylpropyl)pyrrolidin-2-one

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1-Bromo-3-chloropropane Suppliers

Global( 551)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10319	58
Honest Joy Holdings Limited	0755-36694831 +8613717124449	sale@feiyang.com.cn	China	300	58
Jinan Qinmu Fine Chemical Co.,Ltd.	+8618660799346	sales@qinmuchem.com	China	1009	58
Baynoe Chem (Suzhou) Co., Ltd.	+86-512 65869404 +86-18934593683	sales06@baynoe.com	China	257	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12835	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20284	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60

Supplier	Advantage
Hubei Ipure Biology Co., Ltd	58
Honest Joy Holdings Limited	58
Jinan Qinmu Fine Chemical Co.,Ltd.	58
Baynoe Chem (Suzhou) Co., Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from 1-Bromo-3-chloropropane manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-04	1-Bromo-3-chloropropane 109-70-6	US $10.00 / KG	1KG	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-10-25	1-Bromo-3-chloropropane 109-70-6	US $0.00 / kg	1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.
2024-10-11	1-Bromo-3-chloropropane 109-70-6	US $10.00 / KG	1KG	99%	50 ton	Hebei Chuanghai Biotechnology Co,.LTD

1-Bromo-3-chloropropane
109-70-6
US $10.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

1-Bromo-3-chloropropane
109-70-6
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

1-Bromo-3-chloropropane
109-70-6
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co,.LTD

1-Bromo-3-chloropropane Spectrum

1-Bromo-3-chloropropane(109-70-6)MS 1-Bromo-3-chloropropane(109-70-6)¹HNMR 1-Bromo-3-chloropropane(109-70-6)¹³CNMR 1-Bromo-3-chloropropane(109-70-6)IR1 1-Bromo-3-chloropropane(109-70-6)IR2 1-Bromo-3-chloropropane(109-70-6)Raman

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1-bromo-3-chloro-propan omega-Chlorobromopropane Propane,1-bromo-3-chloro- Trimethylene bromide chloride trimethylenebromidechloride TRIMETHYLENE CHLOROBROMIDE TRIMETHYLENE BROMOCHLORIDE BROMOCHLOROPROPANE-1,3 3-BROMOPROPYL CHLORIDE 3-CHLOROPROPYL BROMIDE 1-BROMO-3-CHLOROPROPANE 1-Bromo-3-chlorophenane 1-Bromo-3-Cloropropane Bromochloropropane,99% 1-BROMO-3-CHLOROPROPANE, MOLECULARBIOLOG Y GRADE 1-BROMO-3-CHLOROPROPANE PESTANAL 1-BROMO-3-CHLOROPROPANE, 99+% 1-Bromo-3-Chloropropane,>98% trimethylenbromchlorid 1-Brom-3-chlorpropan 1-Bromo 3-Chlorooropane I-BCP, Trimethylene bromochloride, Trimethylene chlorobromide 1-Bromo-3-chloropropane, 99.5% 1-Bromo-3-chloropropane,I-BCP, Trimethylene bromochloride, Trimethylene chlorobromide 1-Bromo-3-chloroprop 3-Chloropropan-1-yl BroMide NSC 9183 ω-Chlorobr 3-Bromopropyl Chloride 3-Chloropropyl Bromide Trimethylene Bromochloride Trimethylene Chlorobromide 1-BROMO-3-CHLOROPROPANE FOR SYNTHESIS 1-Bromo-3-chloropropane≥ 99.5% (GC) 1,3-Chbp 1,3-chlorbromopropane 1-chloro-3-bromopropane 3-bromopropyl chloride 1- BROMO-3-CHLOROPROPOANE 1-Bromo-3-chloropropane ISO 9001：2015 REACH 1-Bromo-3-chloropropane, for isolation of RNA 1-BROMO-3-CHLOROPROPANE, 99%1-BROMO-3-CHLOROPROPANE, 99%1-BROMO-3-CHLOROPROPANE, 99%1-BROMO-3-CHLOROPROPANE, 99% 1-Bromo-3-chL 1-Bromo-3-chloropropane > 3-Bromo-1-chloropropane 3-Chloro-1-bromopropane BROMOCHLOROPROPANE 1-CHLORO-3-BROMOPROPANE I-BCP CHLOROBROMOPROPANE 1,3-BCP 1-BROMO, 3CHLORO PROPANE (BCP) Trimethylene chlorobromide, Trimethylene bromochloride 1-Bromo-3-chloropropane, ≥ 99.0% 1-Bromo -3-Chloropropane 99% For Synthesis 1-Bromo-3-Chlropropane Ivabradine Impurity 3 1-bromo-3-chloropropane 109-70-6 BrCH23Cl ClCH23Br BrCH2CH2CH2Cl C3H7BrCl