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Sodium cloxacillin monohydrate

Sodium cloxacillin monohydrate Structure
Sodium cloxacillin monohydrate structure
CAS No.
7081-44-9
Chemical Name:
Sodium cloxacillin monohydrate
Synonyms
bactopen;Cloxacillin s;staphobristol-250;Cloxacillin sodium;orbeninsodiumhydrate;α-Amino-p-toluic acid;Cloxacillin sodium CRS;Oxacillin EP Impurity E;prostaphlin-amonohydrate;Cloxacillin Sodium(Oral)
CBNumber:
CB8705413
Molecular Formula:
C19H19ClN3NaO6S
Molecular Weight:
475.88
MDL Number:
MFCD00150735
MOL File:
7081-44-9.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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Sodium cloxacillin monohydrate Properties

Melting point 170℃
Boiling point 689℃
Flash point >110°(230°F)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: soluble50mg/mL
form solid
color White to Orange to Green
Water Solubility Soluble in water
Merck 13,2444
BRN 5403885
CAS DataBase Reference 7081-44-9(CAS DataBase Reference)
FDA UNII 65LCB00B4Y

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H317-H319-H334-H335
Precautionary statements  P261-P280-P284-P304+P340-P305+P351+P338-P342+P311
Hazard Codes  Xn
Risk Statements  36/37/38-42/43
Safety Statements  26-36
WGK Germany  2
RTECS  XH8920000
HS Code  29411099
NFPA 704
0
3 0

Sodium cloxacillin monohydrate price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C9393 Cloxacillin sodium salt monohydrate β-lactamase-resistant antibiotic 7081-44-9 1g $63.8 2024-03-01 Buy
Sigma-Aldrich 1142005 Cloxacillin sodium United States Pharmacopeia (USP) Reference Standard 7081-44-9 200mg $436 2024-03-01 Buy
Sigma-Aldrich BP089 Cloxacillin sodium British Pharmacopoeia (BP) Reference Standard 7081-44-9 125MG $230 2023-01-07 Buy
TCI Chemical C2244 Cloxacillin Sodium Salt Monohydrate >98.0%(HPLC) 7081-44-9 1g $50 2024-03-01 Buy
TCI Chemical C2244 Cloxacillin Sodium Salt Monohydrate >98.0%(HPLC) 7081-44-9 5g $144 2024-03-01 Buy
Product number Packaging Price Buy
C9393 1g $63.8 Buy
1142005 200mg $436 Buy
BP089 125MG $230 Buy
C2244 1g $50 Buy
C2244 5g $144 Buy

Sodium cloxacillin monohydrate Chemical Properties,Uses,Production

Brand Name(s) in US

Cloxapen, Orbenin, Tegopen

Description

Cloxacillin was synthesized by Beecham Research Laboratories in 1962 starting with 6- aminopenicillanic acid. It was the first semisynthetic penicillin with a halogen atom in the side chain to be used clinically. It shows 5- to 20-fold stronger activity than methicillin and is twice as active as oxacillin against Staphylococcus aureus, including benzylpenicillin-resistant strains. Cloxacillin is highly stable against penicillinase and well absorbed by oral administration. It has been widely used, by oral and intramuscular administration, to treat internal, surgical, gynecological, and other infections caused by both benzylpenicillin-sensitive and benzylpenicillin-resistant bacteria.

Chemical Properties

White or almost white, hygroscopic, crystalline powder.

Uses

Penicillin antibacterial.

Uses

Targets primarily Gram-positive bacteria, especially -lactamase producing Staphylococci

Definition

ChEBI: Cloxacillin sodium monohydrate is an organic sodium salt and a hydrate. It contains a cloxacillin sodium.

brand name

Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).

Contact allergens

Cloxacillin is a semisynthetic penicillin close to oxacillin. It induced contact dermatitis in a pharmaceutical factory worker with positive reactions to ampicillin, but not to penicillin. In cutaneous drug reactions such as acute generalized exanthematous pustulosis due to amoxicillin, cross-reactivity is frequent to cloxacillin (personal observations).

Clinical Use

The chlorine atom ortho to the position of attachment of thephenyl ring to the isoxazole ring enhances the activity ofcloxacillin sodium, [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodium monohydrate (Tegopen), over that ofoxacillin, not by increasing its intrinsic antibacterial activitybut by enhancing its oral absorption, leading to higher plasmalevels. In almost all other respects, it resembles oxacillin.

Safety Profile

Moderately toxic by intraperitoneal, intramuscular, subcutaneous, and intravenous routes. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl-, NOx, Na2O, and SOx.

Veterinary Drugs and Treatments

Cloxacillin is used via intramammary infusion in dry and lactating dairy cattle.

Sodium cloxacillin monohydrate Preparation Products And Raw materials

Raw materials

Acetoxyacetic acid Sodium 2-ethylhexanoate Cloxacillin-13C4 SodiuM Salt Phosphorus pentachloride o-Toluidine

Preparation Products

Sodium cloxacillin monohydrate Suppliers

Global( 362)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 998 58
Henan Suikang Pharmaceutical Co.,Ltd. 		+86-18239973690 +86-18239973690 sales@suikangpharm.com China 311 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+86 18953170293 sales@sdzschem.com China 2930 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 954 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd 		58
Henan Suikang Pharmaceutical Co.,Ltd. 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Shenzhen Excellent Biotech Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58

View Lastest Price from Sodium cloxacillin monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sodium cloxacillin monohydrate pictures 2024-11-25 Sodium cloxacillin monohydrate
7081-44-9
 US $0.00 / kg 25kg 99.0% 10tons Henan Suikang Pharmaceutical Co.,Ltd.
Sodium cloxacillin monohydrate pictures 2024-11-22 Sodium cloxacillin monohydrate
7081-44-9
 US $1.00 / KG 1KG ≥825μg 1000kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Cloxacillin sodium monohydrate pictures 2024-11-19 Cloxacillin sodium monohydrate
7081-44-9
 US $30.00-40.00 / mg 97.94% 10g TargetMol Chemicals Inc.

Sodium cloxacillin monohydrate Spectrum

Sodium cloxacillin monohydrate(7081-44-9)MSSodium cloxacillin monohydrate(7081-44-9)IR1Sodium cloxacillin monohydrate(7081-44-9)IR2

7081-44-9(Sodium cloxacillin monohydrate)Related Search:

ETHANE Dimethyl fumarate Dimethyl phthalate Oxacillin sodium monohydrate N,N-Dimethylformamide
Sodium benzoate 3,4'-DIAMINODIPHENYLMETHANE Dimethyl sebacate Sodium acetate Dimethyl carbonate
Dimethyl sulfoxide Sodium hydroxide Sodium bicarbonate Sodium formate Sodium gluconate
Chlorodimethylphenylsilane Dimethyl ether Flucloxacillin sodium

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bactopen brl-1621sodiumsaltmonohydrate cloxacillinsodiummonohydrate CLOXACILLIN SODIUM SALT MONOHYDRATE CLOXACILLIN SODIUM SALT HYDRATE CLOXACILLIN SODIUM SALT N-HYDRATE CLOXACILLIN SODIUM SALT HYDRATE VETRANAL CLOXACILLIN SODIUM EPC(CRM STANDARD) CLOXACILLIN SODIUM USP(CRM STANDARD) CLOXACILLIN SODIUM WHO(CRM STANDARD) Cloxacillin sodium hydrate Cloxacillin monohydrate sodium salt [5-METHYL-3-(O-CHLOROPHENYL)-4-ISOXAZOLYL]PENICILLIN SODIUM SALT MONOHYDRATE 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-3-(2-chlorophenyl)-5-methyl-4-isoxazolylcarbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)- Cloxacillin sodium Sodium 6-[3-(2-chlorophenyl)-5-methyl-oxazol-4-yl]carbonylamino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate 3-(2-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin Sodium orbeninsodiumhydrate prostaphlin-amonohydrate sodiumcloxacillinmonohydrate staphobristol-250 thyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-,sodiumsalt,monohydrate Cloxacillin hydrate sodium salt Cloxacillin Sodium (200 mg) 7-[[3-(2-chlorophenyl)-5-methyl-oxazol-4-yl]carbonylamino]-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid sodium salt Cloxacillin s (2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodium salt, hydrate (1:1:1) Claxacillin Sodium(Sodium) Claxacillin Sodium(Compacted) Clozicillin sodium (oral) Cloxacillin Sodium(Oral) sodium (2S,5R,6R)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate Cloxacilline sodium 1-hydrate Cloxacillin Sodium Salt Monohydrate> Cloxacillin Sodium Salt Monohydrate Standard Cloxacillin sodium CRS Oxacillin EP Impurity E Sodium cloxacillin monohydrate USP/EP/BP Cloxacillin sodiumQ: What is Cloxacillin sodium Q: What is the CAS Number of Cloxacillin sodium Q: What is the storage condition of Cloxacillin sodium Q: What are the applications of Cloxacillin sodium Cloxacillin Sodium Monohydrate (CSX), 95-102% Cloxacillin Sodium (1142005) α-Amino-p-toluic acid (2S,5R,6R)-6-(3-(2-chlorophenyl)-5-Methyl isoxazole-4-formamide)-3,3-twoMethyl-7-oxy-4-sulfur-1-nitrogen bile [3.2.01 Heptane-2-sodium carboxylate hydrate (2S,5R,6R)-6-(3-2-chlorobenzeneBase)-5-Methylisoxazole-4-formamideBase)-3.3-Dimethyl-7-oxygenation-4-Sulfur-1-nitrogen bicyclic[3.2.0]Seventh of the ten Heavenly StemsAlkanes-2-sodium carboxylate hydrate Sodium(2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylatemonohydrate Oxacillin Sodium Monohydrate EP Impurity E as Sodium Salt Monohydrate Cloxacillin sodium hydrate in ACN:H2O (9:1) C11692100 Cloxacillin sodium monohydrate 7081-44-9 C19H17ClN3O5SNaH2O C19H17ClN3O5SNaxH2O C19H17ClN3NaO5SxH2O C19H19ClN3NaO6S C19H17ClN3NaO5SH2O C19H16N3ClO5SNaH2O Antibiotics Antibiotics A-F Antibiotics A to Z