S-(4-NITROBENZYL)-6-THIOINOSINE
- CAS No.
- 38048-32-7
- Chemical Name:
- S-(4-NITROBENZYL)-6-THIOINOSINE
- Synonyms
- NBMPR;NBTI;NSC 296962;nitrobenzylthioinosine;4-nitrobenzylthioinosine;6-(p-nitrobenzylthio)inosine;S6-(4-nitrylbenzyl)thioinosine;S-(4-NITROBENZYL)-6-THIOINOSINE;S-(P-NITROBENZYL)-6-THIOINOSINE;4-Nitrobenzyl-6-mercaptoinosine
- CBNumber:
- CB8713230
- Molecular Formula:
- C17H17N5O6S
- Molecular Weight:
- 419.41
- MDL Number:
- MFCD00005745
- MOL File:
- 38048-32-7.mol
- MSDS File:
- SDS
Melting point | 187-190 °C(lit.) |
---|---|
Boiling point | 770.2±70.0 °C(Predicted) |
Density | 1.3904 (rough estimate) |
refractive index | 1.6460 (estimate) |
storage temp. | 2-8°C |
solubility | 0.1 M HCl: slightly soluble |
form | solid |
pka | 13.08±0.70(Predicted) |
color | white |
CAS DataBase Reference | 38048-32-7(CAS DataBase Reference) |
FDA UNII | GV1L2DZM2Z |
SAFETY
Risk and Safety Statements
Safety Statements | 24/25 |
---|---|
WGK Germany | 3 |
RTECS | UO9025000 |
HS Code | 29349990 |
S-(4-NITROBENZYL)-6-THIOINOSINE price More Price(27)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N2255 | S-(4-Nitrobenzyl)-6-thioinosine ≥98%, solid | 38048-32-7 | 25mg | $83.7 | 2024-03-01 | Buy |
Sigma-Aldrich | N2255 | S-(4-Nitrobenzyl)-6-thioinosine ≥98%, solid | 38048-32-7 | 100mg | $265 | 2024-03-01 | Buy |
Cayman Chemical | 16403 | S-(4-Nitrobenzyl)-6-thioinosine ≥98% | 38048-32-7 | 25mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 16403 | S-(4-Nitrobenzyl)-6-thioinosine ≥98% | 38048-32-7 | 50mg | $78 | 2024-03-01 | Buy |
Sigma-Aldrich | N2255 | S-(4-Nitrobenzyl)-6-thioinosine ≥98%, solid | 38048-32-7 | 250mg | $528 | 2024-03-01 | Buy |
S-(4-NITROBENZYL)-6-THIOINOSINE Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio
Uses
S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
Definition
ChEBI: NBMPR is a purine nucleoside.
General Description
S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S6-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.
Biological Activity
Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
Biochem/physiol Actions
Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.
storage
Store at +4°C
S-(4-NITROBENZYL)-6-THIOINOSINE Preparation Products And Raw materials
S-(4-NITROBENZYL)-6-THIOINOSINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9980 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9365 | 58 |
Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |