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S-(4-NITROBENZYL)-6-THIOINOSINE

S-(4-NITROBENZYL)-6-THIOINOSINE structure

CAS No.: 38048-32-7

Chemical Name:: S-(4-NITROBENZYL)-6-THIOINOSINE

Synonyms: NBMPR;NBTI;NSC 296962;nitrobenzylthioinosine;4-nitrobenzylthioinosine;6-(p-nitrobenzylthio)inosine;S6-(4-nitrylbenzyl)thioinosine;S-(4-NITROBENZYL)-6-THIOINOSINE;S-(P-NITROBENZYL)-6-THIOINOSINE;4-Nitrobenzyl-6-mercaptoinosine

CBNumber:: CB8713230

Molecular Formula:: C17H17N5O6S

Molecular Weight:: 419.41

MDL Number:: MFCD00005745

MOL File:: 38048-32-7.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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S-(4-NITROBENZYL)-6-THIOINOSINE Properties

Melting point	187-190 °C(lit.)
Boiling point	770.2±70.0 °C(Predicted)
Density	1.3904 (rough estimate)
refractive index	1.6460 (estimate)
storage temp.	2-8°C
solubility	0.1 M HCl: slightly soluble
form	solid
pka	13.08±0.70(Predicted)
color	white
CAS DataBase Reference	38048-32-7(CAS DataBase Reference)
FDA UNII	GV1L2DZM2Z

SAFETY

Risk and Safety Statements

Safety Statements	24/25
WGK Germany	3
RTECS	UO9025000
HS Code	29349990

S-(4-NITROBENZYL)-6-THIOINOSINE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N2255	S-(4-Nitrobenzyl)-6-thioinosine ≥98%, solid	38048-32-7	25mg	$83.7	2024-03-01	Buy
Sigma-Aldrich	N2255	S-(4-Nitrobenzyl)-6-thioinosine ≥98%, solid	38048-32-7	100mg	$265	2024-03-01	Buy
Cayman Chemical	16403	S-(4-Nitrobenzyl)-6-thioinosine ≥98%	38048-32-7	25mg	$57	2024-03-01	Buy
Cayman Chemical	16403	S-(4-Nitrobenzyl)-6-thioinosine ≥98%	38048-32-7	50mg	$78	2024-03-01	Buy
Sigma-Aldrich	N2255	S-(4-Nitrobenzyl)-6-thioinosine ≥98%, solid	38048-32-7	250mg	$528	2024-03-01	Buy

Product number	Packaging	Price	Buy
N2255	25mg	$83.7	Buy
N2255	100mg	$265	Buy
16403	25mg	$57	Buy
16403	50mg	$78	Buy
N2255	250mg	$528	Buy

S-(4-NITROBENZYL)-6-THIOINOSINE Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio

Uses

S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.

Definition

ChEBI: NBMPR is a purine nucleoside.

General Description

S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S⁶-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.

Biological Activity

Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Biochem/physiol Actions

Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.

storage

Store at +4°C

S-(4-NITROBENZYL)-6-THIOINOSINE synthesis

Synthesis of S-(4-NITROBENZYL)-6-THIOINOSINE from 1-O-ACETYL-2,3,5-TRI-O-BENZOYL-D-RIBOFURANOSE

S-(4-NITROBENZYL)-6-THIOINOSINE Preparation Products And Raw materials

Raw materials

[3,4-dibenzoyloxy-5-(6-chloropurin-9-yl)oxolan-2-yl]methyl benzoate 6-Chloropurine ribonucleoside 2,3,5-TRI-O-ACETYL-6-CHLOROPURINE-9--D-RIBOFURANOSIDE 1-O-ACETYL-2,3,5-TRI-O-BENZOYL-D-RIBOFURANOSE 4-nitrobenzyl mercaptan

4-Nitrobenzyl chloride 6-Chloropurine

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Preparation Products

S-(4-NITROBENZYL)-6-THIOINOSINE Suppliers

Global( 99)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9980	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9363	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32343	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Nanjing Baifuli Technology Co., Ltd.	58
NewCan Biotech Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
DONBOO AMINO ACID COMPANY	58
Mainchem Co., Ltd.	55
J & K SCIENTIFIC LTD.	76

S-(4-NITROBENZYL)-6-THIOINOSINE Spectrum

S-(4-NITROBENZYL)-6-THIOINOSINE(38048-32-7)¹HNMR S-(4-NITROBENZYL)-6-THIOINOSINE(38048-32-7)Raman

38048-32-7(S-(4-NITROBENZYL)-6-THIOINOSINE)Related Search:

S-(2-HYDROXY-5-NITROBENZYL)-6-THIOINOSINE S-(P-NITROBENZYL)-6-THIOINOSINE, [3H]- NITROBENZYLTHIOINOSINE, [BENZYL-3H]- S-(4-NITROBENZYL)-6-THIOINOSINE 6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE-5'-MONOPHOSPHATE, DISODIUM SALT

NBTGR

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S-(P-NITROBENZYL)-6-THIOINOSINE S-(4-NITROBENZYL)-6-THIOINOSINE NBTI 4-nitrobenzylthioinosine 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine 6-(p-nitrobenzylthio)inosine 6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE nitrobenzylthioinosine S-(4-NITROBENZYL)-6-THIOINOSINE (NBTI) P OTENT ADENOSINE UPTA S-(P-NITROBENZYL)-6-THIOINOSINE 98+% S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) 6-[(4-nitrobenzyl)thio]-9-β-d-ribofuranosylpurine 6-[(4-Nitrobenzyl)-mercapto]-inosine 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine NSC 296962 S-(p-Nitrobenzyl)-6-mercapto-9--D-ribofuranosylpurine NBMPR, NBTI, 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine 4-Nitrobenzyl-6-mercaptoinosine 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosyl-9H-purine 6-[[(4-Nitrophenyl)methyl]thio]-9-(β-D-ribofuranosyl)-9H-purine S-(4-Nitrobenzyl)-6-thioinosine,99% (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol Inosine, 6-S-[(4-nitrophenyl)methyl]-6-thio- NBMPR S6-(4-nitrylbenzyl)thioinosine 38048-32-7 C17H17N5O6S Bases & Related Reagents Heterocycles Inhibitors Nucleotides Sulfur & Selenium Compounds