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4-chloro-6,7-dimethoxyquinoline

4-chloro-6,7-dimethoxyquinoline structure

CAS No.: 35654-56-9

Chemical Name:: 4-chloro-6,7-dimethoxyquinoline

Synonyms: 4-Chloro-6,7-dimethoxyquioline;4-CHLORO-6;7-DIMETHOXYQUINOLINE;oro-6,7-dimethoxyquinoL;Cabozantinib Impurity 71;Cabozantinib Chloro Analog;4-CHLORO-6,7-DIMETHOXYQUINOLINE;6,7-DIMETHOXY-4-CHLOROQUINOLINE;4-Chloro-6,7-dimethoxy-quinolin;Quinoline, 4-chloro-6,7-dimethoxy-

CBNumber:: CB8725015

Molecular Formula:: C11H10ClNO2

Molecular Weight:: 223.66

MDL Number:: MFCD07778437

MOL File:: 35654-56-9.mol

MSDS File:: SDS

Last updated:2023-12-26 17:07:23

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4-chloro-6,7-dimethoxyquinoline Properties

Melting point	132.0 to 136.0 °C
Boiling point	325.2±37.0 °C(Predicted)
Density	1.265±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	3.95±0.30(Predicted)
color	Pale Brown to Light Brown
InChI	InChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3
InChIKey	WRVHQEYBCDPZEU-UHFFFAOYSA-N
SMILES	N1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference	35654-56-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H315-H335

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Hazard Codes

Risk Statements

Safety Statements

45-24/25

RIDADR

UN2811

HazardClass

IRRITANT

HS Code

29334900

NFPA 704

	0
1		0

4-chloro-6,7-dimethoxyquinoline price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS007782	4-chloro-6,7-dimethoxyquinoline AldrichCPR	35654-56-9	250mg	$104	2024-03-01	Buy
TCI Chemical	C2938	4-Chloro-6,7-dimethoxyquinoline >98.0%(GC)	35654-56-9	5g	$94	2024-03-01	Buy
TCI Chemical	C2938	4-Chloro-6,7-dimethoxyquinoline >98.0%(GC)	35654-56-9	25g	$376	2024-03-01	Buy
TRC	C365930	4-Chloro-6,7-dimethoxyquinoline	35654-56-9	1g	$220	2021-12-16	Buy
ChemScene	CS-D1175	4-Chloro-6,7-dimethoxyquinoline 99.65%	35654-56-9	100g	$228	2021-12-16	Buy

Product number	Packaging	Price	Buy
CDS007782	250mg	$104	Buy
C2938	5g	$94	Buy
C2938	25g	$376	Buy
C365930	1g	$220	Buy
CS-D1175	100g	$228	Buy

4-chloro-6,7-dimethoxyquinoline Chemical Properties,Uses,Production

Chemical Properties

Light brown powder

Uses

4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.

Application

4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis.

Synthesis

With 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.
4-chloro-6,7-dimethoxyquinoline synthesis

4-chloro-6,7-dimethoxyquinoline synthesis

Synthesis of 4-chloro-6,7-dimethoxyquinoline from 4-Hydroxy-6,7-dimethoxyqunioline

4-chloro-6,7-dimethoxyquinoline Preparation Products And Raw materials

Raw materials

Butane, 2,2'-oxybis[2-methyl- diethyl {[(3,4-dimethoxyphenyl)amino]methylidene}propanedioate 4-Hydroxy-6,7-dimethoxyqunioline 1-(4,5-DIMETHOXY-2-NITRO-PHENYL)-ETHANONE 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE

2-[2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-6-methylpyran-4-ylidene]propanedinitrile 3,4-Dimethoxyacetophenone 4-Aminoveratrole Acetovanillone tert-Butyl methyl ether

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Preparation Products

4-chloro-6,7-dimethoxyquinoline Suppliers

Global( 393)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20286	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18775	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9206	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58

View Lastest Price from 4-chloro-6,7-dimethoxyquinoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-26	6,7-dimethoxy-4-chloroquinoline 35654-56-9	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2024-01-08	4-Chloro-6,7-dimethoxyquinoline 35654-56-9	US $2.00 / KG	1KG	99%	50000tons	Wuhan Boyuan Import & Export Co., LTD
2024-01-02	4-Chloro-6,7-dimethoxyquinoline 35654-56-9	US $200.00-1.00 / KG	1KG	99%, 99.5% Sublimated	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

6,7-dimethoxy-4-chloroquinoline
35654-56-9
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

4-Chloro-6,7-dimethoxyquinoline
35654-56-9
US $2.00 / KG
99%
Wuhan Boyuan Import & Export Co., LTD

4-Chloro-6,7-dimethoxyquinoline
35654-56-9
US $200.00-1.00 / KG
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

4-chloro-6,7-dimethoxyquinoline Spectrum

4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9)¹HNMR

35654-56-9(4-chloro-6,7-dimethoxyquinoline)Related Search:

Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]- Cabozantinib impurity 1DYH 1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]- Cabozantinib Malate Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]-

Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]- 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Cabozantinib impurity DX2

Cabozantinib Impurity EXA N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide Cabozantinib Impurity 5 4-Aminoveratrole 4-Amino-2-Chloro-6,7-Dimethoxyquinoline

4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE ethyl 4-chloro-5,8-dimethoxyquinoline-3-carboxylate 4-CHLORO-7,8-DIMETHOXYQUINOLINE

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6,7-DIMETHOXY-4-CHLOROQUINOLINE 4-CHLORO-6,7-DIMETHOXYQUINOLINE Quinoline, 4-chloro-6,7-dimethoxy- 4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9) Cabozantinib 4-Chloroquinoline Impurity 4-Chloro-6,7-dimethoxyquinoline > oro-6,7-dimethoxyquinoL Cabozantinib Impurity 71 4-CHLORO-6,7-DIMETHOXYQUINOLINE ISO 9001：2015 REACH 4-CHLORO-6 7-DIMETHOXYQUINOLINE Cabozantinib Chloro Analog 4-Chloro-6,7-dimethoxyquioline 4-Chloro-6,7-dimethoxy-quinolin 4-Chloro-6,7-dimethoxyquinoline carboxylic Acid 35654-56-9 Quinoline&Isoquinoline 35654-56-9