7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
- CAS No.
- 62252-26-0
- Chemical Name:
- 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
- Synonyms
- JLK6;JCP 251);JCP251 (JCP-251;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN;7-Amino-4-chloro-3-methoxy-1H-2-benzopyran;7-Amino-4-chloro-3-methoxy-isochromen-1-one;7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one;1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-;JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β
- CBNumber:
- CB8741619
- Molecular Formula:
- C10H8ClNO3
- Molecular Weight:
- 225.63
- MDL Number:
- MFCD04035584
- MOL File:
- 62252-26-0.mol
- MSDS File:
- SDS
| Melting point | 115 °C |
|---|---|
| Boiling point | 456.1±45.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO (Slightly) |
| form | Solid |
| pka | 1.95±0.20(Predicted) |
| color | Yellow to Beige |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 |
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28712 | JCP251 | 62252-26-0 | 10mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 28712 | JCP251 | 62252-26-0 | 100mg | $961 | 2024-03-01 | Buy |
| Cayman Chemical | 28712 | JCP251 | 62252-26-0 | 50mg | $543 | 2024-03-01 | Buy |
| Cayman Chemical | 28712 | JCP251 | 62252-26-0 | 250mg | $1802 | 2024-03-01 | Buy |
| Tocris | 2677 | JLK6 ≥99%(HPLC) | 62252-26-0 | 50 | $690 | 2021-12-16 | Buy |
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Chemical Properties,Uses,Production
Uses
JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.
Definition
ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.
Biological Activity
Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .
References
[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Preparation Products And Raw materials
Raw materials
Preparation Products
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3576 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Aikon International Limited | 025-66113011 18112977050 | sales01@aikonchem.com | China | 16027 | 58 |
