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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:JLK6
CAS:62252-26-0
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
CAS:62252-26-0
Purity:95%~99.99% heidi@coreychem.com Package:1KG;2.8USD
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one
CAS:62252-26-0
Purity:98%+ Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
Tel: +undefined18143011203
Email: info@chemextension.com
Products Intro: Product Name:7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one
CAS:62252-26-0
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:JLK 6
CAS:62252-26-0
Purity:>=99%(HPLC) Package:$159.9/10mg;$359.9/25mg;$655.9/50mg;$1179.9/100mg;$2654.9/250mg;Bulk package Remarks:99%(HPLC)
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Basic information
Product Name:7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
Synonyms:JLK6;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN;7-Amino-4-chloro-3-methoxy-1H-2-benzopyran;JCP 251);JCP251 (JCP-251;7-Amino-4-chloro-3-methoxy-isochromen-1-one;7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one
CAS:62252-26-0
MF:C10H8ClNO3
MW:225.63
EINECS:
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Mol File:62252-26-0.mol
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Structure
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Chemical Properties
Melting point 115 °C
Boiling point 456.1±45.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO (Slightly)
form Solid
pka1.95±0.20(Predicted)
color Yellow to Beige
Stability:Hygroscopic
Safety Information
MSDS Information
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Usage And Synthesis
UsesJLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.
DefinitionChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.
Biological ActivityInhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .
references[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Preparation Products And Raw materials
Tag:7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN(62252-26-0) Related Product Information
GAMMA-SECRETASE INHIBITOR 2-(Chloromethyl)benzoic acid 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Methyl 2-chloromethylbenzoate 1H-2-Benzopyran-1-one 3-METHOXY-1H-ISOCHROMEN-1-ONE BENZOIC ACID, 5-AMINO-2-METHYL-, METHYL ESTER, HYDROCHLORIDE 1,1-DIMETHOXYETHENE