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NEOMYCIN B

CAS No.
119-04-0
Chemical Name:
NEOMYCIN B
Synonyms
actilin;actiline;framygen;Framidal;Framycin;enterfram;Francetin;Fraquinol;framycetin;NEOMYCIN B
CBNumber:
CB8761428
Molecular Formula:
C23H46N6O13
Molecular Weight:
614.64
MDL Number:
MFCD09788228
MOL File:
119-04-0.mol
Last updated:2023-05-18 11:31:04

NEOMYCIN B Properties

Melting point >194°C (dec.)
Boiling point 658.4°C (rough estimate)
Density 1.3548 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
solubility Aqueous Acid (Slightly), Water (Slightly)
form liquid
pka 12.93±0.70(Predicted)
color clear
Merck 13,6482
Stability Hygroscopic
EWG's Food Scores 1
FDA UNII 4BOC774388
ATC code D09AA01,R01AX08,S01AA07

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P284-P304+P340-P333+P313-P342+P311
Hazard Codes  Xn
Risk Statements  42/43-63-36/37/38
Safety Statements  26-36/37/39-45-36/37-23
WGK Germany  2
8
NFPA 704
0
1 0

NEOMYCIN B price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N1142 Neomycin solution with 10 mg/mL neomycin in 0.9% NaCl, sterile-filtered, BioReagent, suitable for cell culture 119-04-0 20ml $17.3 2024-03-01 Buy
TRC N389983 NeomycinB 119-04-0 10mg $1695 2021-12-16 Buy
Usbiological 285570 Neomycin solution 119-04-0 20g $410 2021-12-16 Buy
Usbiological 165605 Neomycin B 119-04-0 1mg $496 2021-12-16 Buy
Medical Isotopes, Inc. 60608 NeomycinB 119-04-0 1mg $675 2021-12-16 Buy
Product number Packaging Price Buy
N1142 20ml $17.3 Buy
N389983 10mg $1695 Buy
285570 20g $410 Buy
165605 1mg $496 Buy
60608 1mg $675 Buy

NEOMYCIN B Chemical Properties,Uses,Production

Uses

Neomycin C is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.

Definition

ChEBI: A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.

General Description

Chemical structure: aminoglycoside

Biochem/physiol Actions

Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L.Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria

NEOMYCIN B Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 67)Suppliers
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BOC Sciences
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TargetMol Chemicals Inc.
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Career Henan Chemica Co
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
BOC Sciences
16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Alfa Chemistry
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12335 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9891 58
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol neomycine standard solution D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1?3)-O-.beta.-D-ribofuranosyl-(1?5)-O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy- NEOMYCIN STANDARD NEOMYCIN B actilin actiline antibiotique enterfram framycetin framygen soframycin soframycine 4-O-(2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]-2-deoxy-D-streptamine (2R,3S,4R,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-6-(aminomethyl)-3-azanyl-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-bis(azanyl)-3-hydroxy-cyclohexyl]oxy-5-azanyl-oxane-3,4-diol (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol Neomycin solution Antibiotic 10676 Antibiotique EF 185 Dekamycin III Framidal Framycin Francetin Fraquinol Leo Red Dry Cow D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy- NEOMYCIN B USP/EP/BP FRADIOMYCIN B; NEOMYCIN B Neomycin B Hexaacetate 119-04-0 1190-04-0 BioChemical Antibiotics A to Z Antibiotics Antibiotics N-S Mechanism of Action N L - ZAlphabetic NA - NIMore...Close... AminoglycosidesAntibiotics Antibacterial Antibiotics Antibiotics A to Antibiotics by Application Antibiotics N-SAntibiotics Antineoplastic and Immunosuppressive AntibioticsAntibiotics Chemical Structure Class Genetic Marker SelectionAntibiotics Interferes with Protein SynthesisSpectrum of Activity