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GSK-3484862

GSK-3484862 Structure
GSK-3484862 structure
CAS No.
2170136-65-7
Chemical Name:
GSK-3484862
Synonyms
GSK-3484862;GSK-3484862 (GSKMI-714);Benzeneacetamide, α-[[3,5-dicyano-6-(dimethylamino)-4-ethyl-2-pyridinyl]thio]-, (αR)-;inhibit,methyltransferase1,5-Azacytidine,Inhibitor,hypomethylation,Dnmt1,therapies,GSK3484862,DNA MTases,DNA,GSK-3484862,epigenetic,DNA Methyltransferase,DNMTs,GSK 3484862
CBNumber:
CB88054418
Molecular Formula:
C19H19N5OS
Molecular Weight:
365.45
MDL Number:
MFCD32708516
MOL File:
2170136-65-7.mol
Last updated:2024-07-02 08:55:37
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GSK-3484862 Properties

Boiling point 620.5±55.0 °C(Predicted)
Density 1.30±0.1 g/cm3(Predicted)
solubility DMSO:20.83(Max Conc. mg/mL);57.0(Max Conc. mM)
pka 14.62±0.50(Predicted)
form Solid
color Light yellow to yellow

GSK-3484862 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0109599 GSK-3484862 99.94% 2170136-65-7 10mg $250 2021-12-16 Buy
ChemScene CS-0109599 GSK-3484862 99.94% 2170136-65-7 50mg $650 2021-12-16 Buy
Product number Packaging Price Buy
CS-0109599 10mg $250 Buy
CS-0109599 50mg $650 Buy

GSK-3484862 Chemical Properties,Uses,Production

Description

GSK-3484862 is a non-covalent inhibitor for Dnmt1. GSK-3484862 induces DNA hypomethylation to against cancer.

in vitro

In total, methylation mapping supports the conclusion that GSK-3484862 treatment produces a drop in DNA methylation consistent with selective and near complete inhibition of DNMT1._x000D_ _x000D_ Reference: Epigenetics Chromatin. 2021 Dec 15;14(1):56. https://pubmed.ncbi.nlm.nih.gov/34906184/

target

GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer.

GSK-3484862 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-3484862 Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9708 58
Shanghai TuZhi Chemical Co., Ltd. 19542790274 19542790274 2119559397@qq.com China 852 50
Chengdu Peter-like Biotechnology Co., Ltd. 028-81700200 18108052721 2850505130@qq.com China 5182 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10011 58
Chengdu PEIP Pharmaceutical Technology Co., LTD. 028-61715638 18011352545 1242335275@qq.com China 403 58
InvivoChem 13549236410 sales@invivochem.cn China 6749 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai TuZhi Chemical Co., Ltd. 50
Chengdu Peter-like Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
cjbscvictory 58
Chengdu PEIP Pharmaceutical Technology Co., LTD. 58
InvivoChem 58
Beijing Biocreative Technology Co., Ltd. 58
GSK-3484862 inhibit,methyltransferase1,5-Azacytidine,Inhibitor,hypomethylation,Dnmt1,therapies,GSK3484862,DNA MTases,DNA,GSK-3484862,epigenetic,DNA Methyltransferase,DNMTs,GSK 3484862 Benzeneacetamide, α-[[3,5-dicyano-6-(dimethylamino)-4-ethyl-2-pyridinyl]thio]-, (αR)- GSK-3484862 (GSKMI-714) 2170136-65-7