Meptazinol
- CAS No.
- 54340-58-8
- Chemical Name:
- Meptazinol
- Synonyms
- MeptaMizol;MEPTAZINOL;Meptazinol A;Meptazinol-13C-d3;Meptazinol USP/EP/BP;MEPTAZINOL 54340-58-8;3-(3-ethyl-1-Methylazepan-3-yl)phenol;3-(1-Methyl-3-ethylhexahydro-1H-azepine-3-yl)phenol;3-(3-ethylhexahydro-1-methyl-1h-azepin-3-yl)-phenol;Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-
- CBNumber:
- CB8841562
- Molecular Formula:
- C15H23NO
- Molecular Weight:
- 233.35
- MDL Number:
- MFCD00864339
- MOL File:
- 54340-58-8.mol
Melting point | 127-133°C |
---|---|
Boiling point | 354.8±35.0 °C(Predicted) |
Density | 0.997 |
pka | 9.95±0.10(Predicted) |
FDA UNII | 18Y7S5JKZD |
ATC code | N02AX05 |
Meptazinol price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 1MG | $460 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 5MG | $518 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 10MG | $574 | 2021-12-16 | Buy |
Chemenu | CM200523 | 3-(3-ethyl-1-methylazepan-3-yl)phenol 97% | 54340-58-8 | 5g | $505 | 2021-12-16 | Buy |
Meptazinol Chemical Properties,Uses,Production
Originator
Meptid,Wyeth,UK,1983
Uses
Analgesic.
Definition
ChEBI: 3-(3-ethyl-1-methyl-3-azepanyl)phenol is a member of azepanes.
Manufacturing Process
2-(m-Methoxyphenyl)butyronitrile in dry ether was added to a stirred suspension of sodium amide in liquid ammonia. The mixture was stirred for 30 minutes then ethyl-4-iodobutyrate (99.25 g, 0.4 mol) in dry ether (200 ml) was added dropwise. The mixture was stirred at the temperature of refluxing liquid ammonia for 5 hours. Ammonium chloride (10 g) was added and the mixture allowed to warm to room temperature. Water (300 ml) was added, the organic layer separated, washed with water, 2 N sulfuric acid and water. After drying over magnesium sulfate and removing the ether, the product was distilled yielding ethyl 5-cyano-5-(mmethoxyphenyl)heptanoate.
That material was hydrogenated in cyclohexane using a Raney nickel catalyst. The product after distillation was recrystallized from ethyl acetate affording 10.0 g of 6-ethyl-(m-methoxyphenyl)hexahydro-2H-azepin-2one, MP 87°C to 88°C.
The azepinone (9.1 g) in dry tetrahydrofuran (50 ml) and ether (50 ml) was added dropwise to a stirred suspension of aluminum lithium hydride (7.5 g) in dry ether (50 ml). After heating under reflux for 3 hours the reaction mixture was worked up and distilled yielding 7.66 g of a compound which was a colorless oil, BP 108°C to 110°C/0.01 mm.
That product was then heated under reflux with 50% hydrobromic acid for 1.5
hours. The reaction mixture was evaporated to dryness and reevaporated with
three portions of propan-2-ol. The oil obtained was dissolved in propan-2-ol
and diluted with ether. 3-Ethyl-3-(m-hydroxyphenyl)hexahydro-1H-azepine
was obtained. That material in turn was reductively methylated by
hydrogenation in the presence of formaldehyde in absolute ethanol solution to
give 3-ethyl-3-(m-methoxyphenyl)-1-methylhexahydro-1H-azepine.
The methoxy group was converted to a hydroxy group by refluxing with 80%
HBr giving meptazinol hydrobromide.
Therapeutic Function
Analgesic
Clinical Use
Opioid analgesic used for moderate to severe pain
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: possible CNS excitation or
depression with MAOIs - avoid; possible CNS
excitation or depression with moclobemide; possibly
increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with
sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative
effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate
- avoid
Metabolism
Meptazinol is extensively metabolised in the liver and is excreted mainly in the urine as the glucuronide conjugate. Less than 10% of a dose has been recovered from the faeces.
Meptazinol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49403 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23430 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15370 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 | China | 5996 | 58 | |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50003 | 58 |
View Lastest Price from Meptazinol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-02-18 | Meptazinol
54340-58-8
|
US $0.00 / gram | 1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited | ||
2021-06-11 | Meptazinol USP/EP/BP
54340-58-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | ||
2019-07-06 | Meptazinol
54340-58-8
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
- Meptazinol
54340-58-8
- US $0.00 / gram
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
- Meptazinol USP/EP/BP
54340-58-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
- Meptazinol
54340-58-8
- US $2.00 / kg
- 99%
- Career Henan Chemical Co