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2-Chloro-5-nitropyridine

2-Chloro-5-nitropyridine Structure
2-Chloro-5-nitropyridine structure
CAS No.
4548-45-2
Chemical Name:
2-Chloro-5-nitropyridine
Synonyms
Chloro-5-nitropyrid;Chloronitropyridine;Piroctone Impurity 3;3-PYRIDINOL, 6-CHLORO-;2-Chlor-5-nitropyridin;2-choro-5-nitropyridine;Chloronitropyridine,99%;2-Chloro--nitropyridine;3-Nitro-6-chloropyridine;2-Chloro-5-nitropyridine
CBNumber:
CB8853635
Molecular Formula:
C5H3ClN2O2
Molecular Weight:
158.54
MDL Number:
MFCD00006240
MOL File:
4548-45-2.mol
MSDS File:
SDS
Last updated:2024-11-08 10:59:09
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2-Chloro-5-nitropyridine Properties

Melting point 105-108 °C (lit.)
Boiling point 256.6±20.0 °C(Predicted)
Density 1.6616 (rough estimate)
refractive index 1.5500 (estimate)
Flash point 158°C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka -4.22±0.10(Predicted)
form Crystalline Powder
color Light yellow to beige
Water Solubility Solubility in hot methanol. Insoluble in water.
BRN 120453
InChI InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H
InChIKey BAZVFQBTJPBRTJ-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C([N+]([O-])=O)C=C1
CAS DataBase Reference 4548-45-2(CAS DataBase Reference)
NIST Chemistry Reference 2-Chloro-5-nitropyridine(4548-45-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  US7175000
HazardClass  IRRITANT
HS Code  29333990
NFPA 704
1
2 0

2-Chloro-5-nitropyridine price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C61801 2-Chloro-5-nitropyridine 99% 4548-45-2 5g $36.9 2024-03-01 Buy
Sigma-Aldrich C61801 2-Chloro-5-nitropyridine 99% 4548-45-2 25g $78 2024-03-01 Buy
TCI Chemical C0025 2-Chloro-5-nitropyridine >99.0%(GC) 4548-45-2 5g $17 2024-03-01 Buy
TCI Chemical C0025 2-Chloro-5-nitropyridine >99.0%(GC) 4548-45-2 25g $49 2024-03-01 Buy
Alfa Aesar A10709 2-Chloro-5-nitropyridine, 99% 4548-45-2 25g $97.65 2024-03-01 Buy
Product number Packaging Price Buy
C61801 5g $36.9 Buy
C61801 25g $78 Buy
C0025 5g $17 Buy
C0025 25g $49 Buy
A10709 25g $97.65 Buy

2-Chloro-5-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal

Uses

2-Chloro-5-nitropyridine is used as a pharmaceutical intermediate.

Uses

2-chloro-5-nitropyridine is an important pyridine derivative and is an intermediate for synthesizing bactericides, plant growth regulators, antibiotics and other medicaments.

Synthesis

Into a 500 ml four-necked flask equipped with a thermometer, stirring and reflux condenser, 50 g of phosphorus oxychloride, 14.0 g (0.1 mole) of 2-hydroxy-5-nitropyridine prepared in Example 1, 25.0 g (0.12 Mol) Phosphorus pentachloride,Stir and react at 100-105°C for 5 hours,Then the phosphorus oxychloride was recovered by distillation under reduced pressure, and the remainder was slowly poured into 120 grams of ice water, fully stirred, and then a 40wt% aqueous sodium hydroxide solution was neutralized to a pH of 8-9.Separate the layers, extract the aqueous layer with dichloromethane three times, 60 grams each time, combine the organic phases,Washed with 20 grams of saturated brine, then dried with 2.0 grams of anhydrous sodium sulfate, distilled to recover dichloromethane, and dried to obtain 15.1 grams of 2-chloro-5-nitropyridine (I), yield 95.3%, gas purity 99.8 %.

Purification Methods

It crystallises from *benzene or *benzene/pet ether. [Beilstein 20/5 V 452.]

2-Chloro-5-nitropyridine synthesis

2530-26-9
4548-45-2
Synthesis of 2-Chloro-5-nitropyridine from 3-Nitropyridine

2-Chloro-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-nitropyridine Phosphorus oxychloride Nitric acid 2-Aminopyridine 2-Hydroxy-5-nitropyridine
2-Amino-6-chloro-3-nitropyridine 2-Chloro-5-nitropyridin-4-amine

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Preparation Products

4-(5-Nitropyridin-2-yl)morpholine 5-Nitropyridine-2-carboxylic acid 1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL 5-AMINO-2-METHOXY-ISONICOTINIC ACID 6-(1-PYRROLIDINYL)-3-PYRIDINAMINE
1-(5-aminopyridin-2-yl)piperidin-4-ol 3-Amino-6-morpholinopyridine 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE 5-NITRO-2-(1-PYRROLIDINYL)PYRIDINE 5-Amino-2-chloropyridine
5-Amino-2-methylpyridine 2-Methoxy-5-nitropyridine 3-Aminopyridine 5-Aminopyridine-2-carboxylic Acid 5-Amino-2-methoxypyridine
2-Chloro-5-nitropyridin-4-amine NVP-LDE225 2-Methyl-5-nitropyridine

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2-Chloro-5-nitropyridine Suppliers

Global( 668)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenyang TYSChem Co., Ltd.
+86-24-83607930 +8618640359690 sales@honghuchem.com China 403 58
Terma Medicare India Pvt.,Ltd
+8613916485955 shivshanghai@yahoo.com India 150 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12839 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5892 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18153 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20286 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 970 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Supplier Advantage
Shenyang TYSChem Co., Ltd.
58
Terma Medicare India Pvt.,Ltd
58
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Weibang Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
hebei hongtan Biotechnology Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60

View Lastest Price from 2-Chloro-5-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-nitropyridine pictures 2024-11-28 2-Chloro-5-nitropyridine
4548-45-2
 US $30.00 / kg 1kg 98% 2000kg hebei hongtan Biotechnology Co., Ltd
2-Chloro-5-nitropyridine pictures 2024-11-28 2-Chloro-5-nitropyridine
4548-45-2
 US $5.00 / kg 1kg ≥98% 200mt/year Jinan Finer Chemical Co., Ltd
2-Chloro-5-nitropyridine pictures 2024-11-27 2-Chloro-5-nitropyridine
4548-45-2
 US $0.00 / Kg/Drum 1KG 98%min HPLC 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD

2-Chloro-5-nitropyridine Spectrum

2-Chloro-5-nitropyridine(4548-45-2)MS2-Chloro-5-nitropyridine(4548-45-2)1HNMR2-Chloro-5-nitropyridine(4548-45-2)IR12-Chloro-5-nitropyridine(4548-45-2)IR2

4548-45-2(2-Chloro-5-nitropyridine)Related Search:

6-Chloro-2-methyl-3-nitropyridine 2-Chloro-3-cyanopyridine 2-Chloro-5-chloromethylpyridine Pentachloropyridine Clopidol
1-Chloro-3-nitrobenzene 2-Chloro-5-methylpyridine 5-Amino-2-chloropyridine 2-chloro-5-cyanopyridine 2-Chloro-5-fluoropyridine
3-Bromo-6-chloro-2-methylpyridine 5-Bromo-2-chloropyridine 2-Chloro-5-hydroxypyridine 2-CHLORO-5-METHOXYPYRIDINE 2-Chloro-5-iodopyridine
5-Bromo-2-chlorobenzoic acid 2,4-DICHLORO-5-NITROPYRIDINE Difluorochloromethane

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2-Chloro-5-nitropyridine 3-Nitro-6-chloropyridine 2-Chloro-5-nitropyridine, 99% 25GR 5-Nitro-2-chloropyridine 6-Chloro-3-nitropyridine 2-Chloro-5-nitropyridine, 97+% Chloro-5-nitropyrid 2-chloro-5-nitro-pyridin Chloronitropyridine,99% 3-PYRIDINOL, 6-CHLORO- 2-choro-5-nitropyridine 2-CHLORO-5-NITROPYRIDINE (NON-REGULATED) 2-CHLORO-5-NITROPYRIDINE (REGULATED) 2-CHLORO-5-NITROPYRIDINE 99+% Chloronitropyridine 2-Chloro-5-nitropyridine > 5-Bromo-4-methyl-2(2H)-pyridinone 4548-45-2 ISO 9001：2015 REACH 2-Chloro-5-nitropyridine ISO 9001：2015 REACH 2-Chloro--nitropyridine 2-chloro-5-nitripyridine 2-Chlor-5-nitropyridin Piroctone Impurity 3 4548-45-2 4548-48-2 C5H3CIN2O2 Building Blocks Pyridines Heterocyclic Building Blocks Halogenated Heterocycles alkyl chloride |nitro-compound Chlorinated heterocyclic series Chloropyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridine series Halides Pyridines derivates Pyridines, Pyrimidines, Purines and Pteredines Heterocycles blocks Pyridines Pyridine compounds of pyridine 1 bc0001