NVP-LDE225
- CAS No.
- 956697-53-3
- Chemical Name:
- NVP-LDE225
- Synonyms
- Sonidegib;Erismodegib;LDE225;CS-65;AZP-577;NVP-LDE225;Sonidegib HCL;SONIDEGIB(LDE225);LDE225 (NVP-LDE225);LDE-225 (SONIDEGIB)
- CBNumber:
- CB52515129
- Molecular Formula:
- C26H26F3N3O3
- Molecular Weight:
- 485.5
- MDL Number:
- MFCD16038928
- MOL File:
- 956697-53-3.mol
- MSDS File:
- SDS
| Melting point | 154-157°C |
|---|---|
| Boiling point | 544.5±50.0 °C(Predicted) |
| Density | 1.255 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White solid. |
| pka | 9.53±0.70(Predicted) |
| color | Light Purple |
| NCI Dictionary of Cancer Terms | erismodegib; LDE225 |
| FDA UNII | 0RLU3VTK5M |
| NCI Drug Dictionary | sonidegib |
| ATC code | L01XJ02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P280-P261 |
| HS Code | 2934999090 |
NVP-LDE225 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E615200 | Erismodegib | 956697-53-3 | 10mg | $130 | 2021-12-16 | Buy |
| ChemScene | CS-0904 | Sonidegib 99.64% | 956697-53-3 | 50mg | $180 | 2021-12-16 | Buy |
| ApexBio Technology | B2266 | LDE225(NVP-LDE225,Erismodegib) | 956697-53-3 | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| ChemScene | CS-0904 | Sonidegib 99.64% | 956697-53-3 | 5mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-0904 | Sonidegib 99.64% | 956697-53-3 | 10mg | $84 | 2021-12-16 | Buy |
NVP-LDE225 Chemical Properties,Uses,Production
Uses
A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.
Definition
ChEBI: A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as it phosphate salt) for treatment of locally advanced basal cell carcinoma.
Biological Activity
lde225 is a potent and selective inhibitor of smoothened with ic50 values of 1.3nm in mouse and 2.5nm in human, respectively [1].lde225 is screened out from a high-throughput cell-based screen of in-house diversity combinatorial libraries and is developed to be an antagonist of smo. smo is an activator of the hedgehog(hh) signaling pathway and aberrant activation links to tumorigenesis in several cancers. the antitumor efficacy of lde225 has been evaluated in vivo. in the subcutaneous ptch+/-p53-/- medulloblastoma allograft mouse model, lde225 can significantly inhibit tumor growth at a dose of 5mg/kg/day. and in an orthotopic ptch+/-p53-/- medulloblastoma allograft model, lde225 is suggested to penetrate the blood-brain barrier in tumor-bearing animals and cause the tumor growth inhibition after 4 days of treatment. additionally, the preclinical safety assays show that lde225 has no genotoxicity and has good selectivity [1].
target
human Hedgehog
storage
Store at -20°C
References
[1] shifeng pan, xu wu, jiqing jiang, et al. discovery of nvp-lde225, a potent and selective smoothened antagonist. acs med. chem. lett. 2010, 1: 130–134.
NVP-LDE225 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
View Lastest Price from NVP-LDE225 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Sonidegib
956697-53-3
|
US $54.00-118.00 / mg | 99.97% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | NVP-LDE225
956697-53-3
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- Sonidegib
956697-53-3
- US $54.00-118.00 / mg
- 99.97%
- TargetMol Chemicals Inc.
-
- NVP-LDE225
956697-53-3
- US $2.00 / kg
- 99%
- Career Henan Chemical Co