L-Alanine, L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-alanyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-lysyl-L-lysyl-
- CAS No.
- 184776-51-0
- Chemical Name:
- L-Alanine, L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-alanyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-lysyl-L-lysyl-
- Synonyms
- L-Alanine, L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-alanyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-lysyl-L-lysyl-
- CBNumber:
- CB89322275
- Molecular Formula:
- C132H228N38O27
- Molecular Weight:
- 2779.46
- MDL Number:
- MFCD08460346
- MOL File:
- 184776-51-0.mol
L-Alanine, L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-alanyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-lysyl-L-lysyl- Properties
| Boiling point | 2489.3±65.0 °C(Predicted) |
|---|---|
| Density | 1.201±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
L-Alanine, L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-alanyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-lysyl-L-lysyl- Chemical Properties,Uses,Production
Description
LAH4 is an antimicrobial peptide that strongly interacts with phospholipid membranes, exhibiting in vitro transfection efficiency.
LAH4 exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities[1]. LAH4 mediates the transport of functional β-galactosidase, a large tetrameric protein of about 0.5 MDa, into the cell interior[2]. At acidic pH, LAH4 has exhibited a high tendency to interact strongly with and be adsorbed on anionic membrane[3].
References
[1]. Perrone B, et al. Lipid interactions of LAH4, a peptide with antimicrobial and nucleic acid transfection activities. Eur Biophys J. 2014 Nov;43(10-11):499-507. [2]. Moulay G, et al. Histidine-rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo. J Pept Sci. 2017 Apr;23(4):320-328. [3]. Islami M, et al. Study of orientation and penetration of LAH4 into lipid bilayer membranes: pH and composition dependence. Chem Biol Drug Des. 2014 Aug;84(2):242-52.
L-Alanine, L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-alanyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-lysyl-L-lysyl- Preparation Products And Raw materials
Raw materials
Preparation Products
L-Alanine, L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-alanyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-histidyl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-lysyl-L-lysyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10312 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | Caroline@youngshechem.com | China | 4905 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6526 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 13355716090 | Sales@gotopbio.com | China | 2844 | 58 |
| Shaoxing Junyu Biotechnology Co., LTD | 0571-88211921 15572296305 | sales4@gotopbio.com | China | 5145 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 6213 | 58 |
| Hangzhou Baige Pharmaceutical Technology Co. , Ltd. | 0571-85350119 15888826472 | 15888826472@163.com | China | 2729 | 58 |
| Shanghai HongTide Biotechnology Co.,Ltd. | 19961912513 | sales@hongtide.com | China | 4682 | 58 |