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VU6007477

VU6007477 structure

CAS No.: 2220141-46-6

Chemical Name:: VU6007477

Synonyms: VU6007477;1H-Pyrrolo[2,3-b]pyridine-6-carboxamide, 1-methyl-4-[[6-(1-methyl-1H-pyrazol-4-yl)-3-pyridinyl]methyl]-N-(tetrahydro-2H-pyran-4-yl)-

CBNumber:: CB89636763

Molecular Formula:: C24H26N6O2

Molecular Weight:: 430.5

MDL Number:

MOL File:: 2220141-46-6.mol

Last updated:2023-03-31 09:12:58

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VU6007477 Properties

Boiling point	711.3±60.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
pka	12.07±0.20(Predicted)

VU6007477 Chemical Properties,Uses,Production

Description

VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat braiplasma Kp = 0.28, Kp,uu = 0.32; mouse Kp = 0.16, Kp,uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures).

VU6007477 Preparation Products And Raw materials

Raw materials

Preparation Products

VU6007477 Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	994	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28091	58

Supplier	Advantage
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58

VU6007477 1H-Pyrrolo[2,3-b]pyridine-6-carboxamide, 1-methyl-4-[[6-(1-methyl-1H-pyrazol-4-yl)-3-pyridinyl]methyl]-N-(tetrahydro-2H-pyran-4-yl)- 2220141-46-6