Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)-
- CAS No.
- 941521-45-5
- Chemical Name:
- Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)-
- Synonyms
- BAZ1A-IN-1;1-(3-Nitrophenyl)-3-(4-phenylthiazol-2-yl)urea;Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)-;leukemia,breast cancer,Epigenetic Reader Domain,BAZ1A IN 1,cancer,ZR-75–30,BAZ1A,BAZ1AIN1,THP-10,bromodomain-containing,lung cancer,H1975,inhibit,BAZ-1A-IN-1,BT474,Inhibitor
- CBNumber:
- CB89968521
- Molecular Formula:
- C16H12N4O3S
- Molecular Weight:
- 340.36
- MDL Number:
- MOL File:
- 941521-45-5.mol
Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Chemical Properties,Uses,Production
Biological Activity
BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1]. BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].
References
[1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.
Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- Suppliers
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 9994 | 55 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 4192 | 55 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
Shandong Jirun Biomedical Technology Co., Ltd. | 0539-0539-8613587 17661611089 | 2639273505@qq.com | China | 165 | 58 |
Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 3336 | 58 |
Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62163 | 58 |