ChemicalBook >> CAS DataBase List >>1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]-
1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]-
- CAS No.
- 1675206-11-7
- Chemical Name:
- 1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]-
- Synonyms
- ARN6039;ARN-6039;ARN 6039;1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]-
- CBNumber:
- CB910756817
- Molecular Formula:
- C21H21F3N2O3
- Molecular Weight:
- 406.4
- MDL Number:
- MOL File:
- 1675206-11-7.mol
Last updated:2023-03-31 09:12:58
1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]- Chemical Properties,Uses,Production
Description
ARN-6039 (being developed by Arrien), is a Potent, Orally Available Inverse Agonist of RORgammat for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against ROR?t was demonstrated in a ROR?t-activated IL-17A Prom/LUCPorter assay in HEK 293 cells (360 nM) and in IL-17 release from CD4+T cell assays (220 nM). The compound also possesses ideal CNS drug-like criteria, exhibited excellent pharmacokinetics (%F: 37), pharmacodynamics, and correlative PK/PD and ADME characteristics.
1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]- Suppliers
Global( 3)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39009 | 58 |
PharmaBlock Sciences (Nanjing), Inc. | 4000255188 | sun_dan@PharmaBlock.com | China | 7268 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
Suzhou ARTK Medchem Co., Ltd. | 58 |
PharmaBlock Sciences (Nanjing), Inc. | 58 |
1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]-
ARN 6039
ARN6039
ARN-6039
1675206-11-7