BUCLIZINE
- CAS No.
- 82-95-1
- Chemical Name:
- BUCLIZINE
- Synonyms
- ah2526;AH 2526;Postafen;Bucladin;Buclifen;Buclozin;BUCLIZINE;Hitabutyzyne;Histabutyzine;Histabutizine
- CBNumber:
- CB9111794
- Molecular Formula:
- C28H33ClN2
- Molecular Weight:
- 433.03
- MDL Number:
- MFCD00242701
- MOL File:
- 82-95-1.mol
| Boiling point | bp0.001 217-220° |
|---|---|
| Density | 0.9970 (rough estimate) |
| refractive index | 1.5940 (estimate) |
| pka | 6.84±0.10(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | 0C94V6X681 |
| ATC code | R06AE01,R06AE51 |
BUCLIZINE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 443556 | Buclizine | 82-95-1 | 2.5mg | $602 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT61369 | Buclizine | 82-95-1 | 10mg | $775 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009055 | BUCLIZINE 95.00% | 82-95-1 | 1G | $1358.28 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT61369 | Buclizine | 82-95-1 | 25mg | $1737.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT61369 | Buclizine | 82-95-1 | 50mg | $3250 | 2021-12-16 | Buy |
BUCLIZINE Chemical Properties,Uses,Production
Originator
Longifine,UCB
Uses
Buclizine is an antinauseant.
Definition
ChEBI: An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.
Manufacturing Process
1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.
brand name
Bucladin (Stuart).
Therapeutic Function
Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant
Synthesis
Buclizine is mainly used in the prevention of motion sickness and in combination with analgesics for treatment of migraine.
BUCLIZINE Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9314 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 988 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8670 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | sales@senfeida.com | China | 23046 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19885 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12984 | 57 |
