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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED structure

CAS No.: 2719051-84-8

Chemical Name:: INDEX NAME NOT YET ASSIGNED

Synonyms

CBNumber:: CB911554052

Molecular Formula:: C79H98Cl2N14O13S3

Molecular Weight:: 1618.81

MDL Number:

MOL File:: Mol file

Last updated:2024-07-02 08:55:39

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INDEX NAME NOT YET ASSIGNED Properties

Density	1.39±0.1 g/cm3(Predicted)
solubility	Soluble to 50 mM in DMSO
pka	13.52±0.46(Predicted)
form	Solid
color	White to light yellow

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

SIM1 is a potent and selective trivalent PROTAC? Degrader based on BET bromodomain inhibitors linked to a Von Hippel Lindau (VHL) ligand via branched linkers. SIM1 degrades all BET family proteins with a preference for BRD2 (DC50 values = 0.7 nM, 1.1 nM and 3.3 nM for BRD4, BRD2 and BRD3, respectively). SIM1 degrades BRD2 more significantly and rapidly than BRD3 and BRD4, and degrades BET proteins with a higher potency than a bivalent degrader. SIM1 also decreases protein levels for Myc and HMOX1 and induces apoptosis in prostate cancer cells.

storage

Store at -20°C

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Easy CDMO Co.,Ltd	021-61734564	August@easycdmo.com	China	10030	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	ET-market@chemextension.com	China	25849	58

Supplier	Advantage
Shanghai Easy CDMO Co.,Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58

2719051-84-8