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N-Hydroxy-5-norbornene-2,3-dicarboximide

N-Hydroxy-5-norbornene-2,3-dicarboximide structure

CAS No.: 21715-90-2

Chemical Name:: N-Hydroxy-5-norbornene-2,3-dicarboximide

Synonyms: HONB;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE;2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;N-Hydroxy-5-norborne;LABOTEST-BB LT00112336;Endo-N-Hydroxy-5-Norbornene-2,;N-Hydroxynorborna-5-ene-2,3-dicarbimide;N-Hydroxy-5-Norborene-2,3-Dicarboximide;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE;N-hydroxynorborn-5-ene-2,3-dicarboximide

CBNumber:: CB9121858

Molecular Formula:: C9H9NO3

Molecular Weight:: 179.17

MDL Number:: MFCD00167583

MOL File:: 21715-90-2.mol

Last updated:2025-03-21 14:41:52

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N-Hydroxy-5-norbornene-2,3-dicarboximide Properties

Melting point	165-170 °C (lit.)
Boiling point	311.69°C (rough estimate)
Density	1.2822 (rough estimate)
refractive index	1.5600 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in ethanol
form	Solid
pka	9.00±0.20(Predicted)
color	Off-White
BRN	13540
CAS DataBase Reference	21715-90-2(CAS DataBase Reference)
EPA Substance Registry System	4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy- (21715-90-2)
UNSPSC Code	12352300
NACRES	NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

TSCA

Yes

HS Code

29280090

NFPA 704

	0
2		0

N-Hydroxy-5-norbornene-2,3-dicarboximide price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	226378	N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97%	21715-90-2	50g	$203	2024-03-01	Buy
TCI Chemical	H0528	N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T)	21715-90-2	25g	$34	2024-03-01	Buy
TCI Chemical	H0528	N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T)	21715-90-2	250g	$185	2024-03-01	Buy
Alfa Aesar	A13205	endo-N-Hydroxy-5-norbornene-2,3-dicarboximide, 97%	21715-90-2	10g	$33.65	2024-03-01	Buy
Alfa Aesar	A13205	endo-N-Hydroxy-5-norbornene-2,3-dicarboximide, 97%	21715-90-2	50g	$125.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
226378	50g	$203	Buy
H0528	25g	$34	Buy
H0528	250g	$185	Buy
A13205	10g	$33.65	Buy
A13205	50g	$125.65	Buy

N-Hydroxy-5-norbornene-2,3-dicarboximide Chemical Properties,Uses,Production

Description

N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has antiviral activity and is used to treat HIV infections. It inhibits the reverse transcriptase enzyme in the virus, which blocks the synthesis of viral DNA. The ferroelectric properties of NHD were first observed by observing changes in its melting point when mixed with water. This property makes it useful for diagnosis purposes. In animal studies, a dose of 5 mg/kg was found to be effective against cancer cells and the drug showed no toxicity in humans at doses up to 500 mg/day. The optimal reaction conditions for NHD are pH 6 and temperature 45 degrees Celsius.

Chemical Properties

white to off-white crystalline powder

Uses

It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.

Uses

Inhibits racemization in peptide synthesis using DCC as condensing agent.

Uses

N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.

Purification Methods

Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]

N-Hydroxy-5-norbornene-2,3-dicarboximide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Hydroxy-5-norbornene-2,3-dicarboximide Suppliers

Global( 291)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Triumpharm Co.,Ltd	+86-02586182925 +86-15105172550	info@triumpharm.com	China	129	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19843	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1001	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58

Supplier	Advantage
Nanjing Triumpharm Co.,Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
AB PharmaTech,LLC	55
Shanxi Naipu Import and Export Co.,Ltd	58
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from N-Hydroxy-5-norbornene-2,3-dicarboximide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2025-03-22	N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2023-02-28	N-Hydroxy-5-norbornene-2,3-dicarboximide 21715-90-2	US $0.00-0.00 / G	1G	99.9%	20ton	Puyang Huicheng Electronic Materials Co., Ltd.

N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
US $0.00-0.00 / G
99.9%
Puyang Huicheng Electronic Materials Co., Ltd.

N-Hydroxy-5-norbornene-2,3-dicarboximide Spectrum

N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)MS N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)¹HNMR N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)¹³CNMR N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)IR1 N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)IR2 N-Hydroxy-5-norbornene-2,3-dicarboximide(21715-90-2)Raman

21715-90-2(N-Hydroxy-5-norbornene-2,3-dicarboximide)Related Search:

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ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 97 N-BENZYLOXYCARBONYLOXY-5-NORBORNENE-2,3-DICARBOXIMIDE, 99 N-Hydroxy-5-norbornene-2,3-dicarboximide

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N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIMIDE N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLIC ACID IMIDE N-HYDROXYBICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXIMIDE LABOTEST-BB LT00112336 3(2h)-dione,3a,4,7,7a-tetrahydro-2-hydroxy-7-methano-1h-isoindole-1 HONB, N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide 3a,4,7,7a-Tetrahydro-2-hydroxy-4,7-methano-1H-isoindole-1,3(2H)-dione 4-Hydroxy-4-azatricyclo[5.2.1.02,6]deca-8-ene-3,5-dione N-Hydroxybicyclo[2.2.1]hepta-5-ene-2,3-dicarbimide N-Hydroxynorborna-5-ene-2,3-dicarbimide N-Hydroxybicyclo[2.2.1]-5-heptene-2,3-dicarboxiMide N-Hydroxy-5-norborne N-Hydroxy-5-norbornene-endo-2,3-dicarboximide97% N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97% N-Hydroxy-5-norbornene-2.3-dicarboxylic imide endo-N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarbo Honb(N-Hydrozy-5-Norbornene-2.3-DicarboxylicImide) N-Hydroxy-5-Norborene-2,3-Dicarboximide N-Hydroxy-5-norbornene-2,3-dicarboximide, 99+% Endo-N-Hydroxy-5-Norbornene-2, HONB N-Hydroxy-5-norbornene-endo-2,3-dicarboximide N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide HONB, endo-N-Hydroxy-5-norbornene-2,3-dicarboximide ENDO-N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE HONB HONB N-HYDROXY-5-NORBORNENE-2.3-DICARBOXYLIMIDE N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE (HONB) N-hydroxynorborn-5-ene-2,3-dicarboximide N-Hydroxy-5-norbornene- 2,3-dicarboxylicacid imide,endo-N-Hydroxy-5- norbornene-2,3-dicarboximide N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE (HONB) N-HYDROXY-5-NORBONENE-2,3-DICARBOXYLIC IMIDE N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] N-Hydroxy-5-norbornene-2,3-dicarboximide USP/EP/BP TIANFU-CHEM 21715-90-2 N-Hydroxy-5-norbornene-2,3-dicarboximide 4-hydroxy-4-azatricyclo[5.2.1.02,]dec-8-ene-3,5-dione N-Hydroxy-5-norbornene-2,4-dicarboximide N-hydroxy-5-norbornene-2.3-dicarboxylimide(HONB) N-Hydroxy-5-norbornene-2,3-dicarboximide[forPeptideSynthesis]> N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE HONB 2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione N-Hydroxy-5-Norbornene-2,3-dimethylimide N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 21715-90-2 5C9H9NO3 Synthetic Reagents Coupling Coupling Reactions (Peptide Synthesis) Peptide Synthesis Condensation & Active Esterification Active Esters/Additives Coupling Reagent Medical Intermediates Biochemistry Condensation & Active Esterification Coupling Reactions (Peptide Synthesis) Peptide Synthesis Synthetic Organic Chemistry