N-Hydroxy-5-norbornene-2,3-dicarboximide
- CAS No.
- 21715-90-2
- Chemical Name:
- N-Hydroxy-5-norbornene-2,3-dicarboximide
- Synonyms
- HONB;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXYLIC ACID IMIDE;2-Hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;N-Hydroxy-5-norborne;LABOTEST-BB LT00112336;Endo-N-Hydroxy-5-Norbornene-2,;N-Hydroxynorborna-5-ene-2,3-dicarbimide;N-Hydroxy-5-Norborene-2,3-Dicarboximide;N-HYDROXY-5-NORBORNENE-2,3-DICARBOXIMIDE;N-hydroxynorborn-5-ene-2,3-dicarboximide
- CBNumber:
- CB9121858
- Molecular Formula:
- C9H9NO3
- Molecular Weight:
- 179.17
- MDL Number:
- MFCD00167583
- MOL File:
- 21715-90-2.mol
Melting point | 165-170 °C (lit.) |
---|---|
Boiling point | 311.69°C (rough estimate) |
Density | 1.2822 (rough estimate) |
refractive index | 1.5600 (estimate) |
storage temp. | Sealed in dry,2-8°C |
solubility | Soluble in ethanol |
form | Solid |
pka | 9.00±0.20(Predicted) |
color | Off-White |
BRN | 13540 |
CAS DataBase Reference | 21715-90-2(CAS DataBase Reference) |
EPA Substance Registry System | 4,7-Methano-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-hydroxy- (21715-90-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29280090 | |||||||||
NFPA 704 |
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N-Hydroxy-5-norbornene-2,3-dicarboximide price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 226378 | N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide 97% | 21715-90-2 | 50g | $203 | 2024-03-01 | Buy |
TCI Chemical | H0528 | N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T) | 21715-90-2 | 25g | $34 | 2024-03-01 | Buy |
TCI Chemical | H0528 | N-Hydroxy-5-norbornene-2,3-dicarboximide [for Peptide Synthesis] >99.0%(T) | 21715-90-2 | 250g | $185 | 2024-03-01 | Buy |
Alfa Aesar | A13205 | endo-N-Hydroxy-5-norbornene-2,3-dicarboximide, 97% | 21715-90-2 | 10g | $33.65 | 2024-03-01 | Buy |
Alfa Aesar | A13205 | endo-N-Hydroxy-5-norbornene-2,3-dicarboximide, 97% | 21715-90-2 | 50g | $125.65 | 2024-03-01 | Buy |
N-Hydroxy-5-norbornene-2,3-dicarboximide Chemical Properties,Uses,Production
Description
N-Hydroxy-5-norbornene-2,3-dicarboximide (NHD) is a compound that has antiviral activity and is used to treat HIV infections. It inhibits the reverse transcriptase enzyme in the virus, which blocks the synthesis of viral DNA. The ferroelectric properties of NHD were first observed by observing changes in its melting point when mixed with water. This property makes it useful for diagnosis purposes. In animal studies, a dose of 5 mg/kg was found to be effective against cancer cells and the drug showed no toxicity in humans at doses up to 500 mg/day. The optimal reaction conditions for NHD are pH 6 and temperature 45 degrees Celsius.
Chemical Properties
white to off-white crystalline powder
Uses
It decreases racemization in peptide synthesis and inhibits formation of N-acylureas.
Uses
Inhibits racemization in peptide synthesis using DCC as condensing agent.
Uses
N-Hydroxy-5-norbornene-2,3-dicarboximide(HONB) is used in solution-phase peptide synthesis. Used in the synthesis of enkephalin analogs.
Purification Methods
Dissolve the imide in CHCl3, filter, evaporate and recrystallise from EtOAc. IR (nujol): max 1695, 1710 and 1770 (C=O), and 3100 (OH) cm-1. The O-acetyl derivative has m 113-114o (from EtOH) with IR bands at max 1730, 1770 and 1815 cm-1 only, and the O-benzoyl derivative has m 143-144o (from propan-2-ol or *C6H6). [Bauer & Miarka J Org Chem 24 1293 1959, Fujino et al. Chem Pharm Bull Jpn 22 1857 1974]. [Beilstein 21/10 V 188.]
N-Hydroxy-5-norbornene-2,3-dicarboximide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Nanjing Triumpharm Co.,Ltd | +86-02586182925 +86-15105172550 | info@triumpharm.com | China | 129 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16911 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29892 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10312 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from N-Hydroxy-5-norbornene-2,3-dicarboximide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2023-02-28 | N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
|
US $0.00-0.00 / G | 1G | 99.9% | 20ton | Puyang Huicheng Electronic Materials Co., Ltd. | |
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2022-09-27 | N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
![]() |
2022-02-25 | N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
|
US $10.00 / KG | 1KG | 99% | 5000kg/month | Shanxi Naipu Import and Export Co.,Ltd |
-
- N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
- US $0.00-0.00 / G
- 99.9%
- Puyang Huicheng Electronic Materials Co., Ltd.
-
- N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- N-Hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2
- US $10.00 / KG
- 99%
- Shanxi Naipu Import and Export Co.,Ltd