BIIE 0246
- CAS No.
- 246146-55-4
- Chemical Name:
- BIIE 0246
- Synonyms
- BIIE 0246;AR-H 053591;BIIE-0246;BIIE0246;N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-;(2S)-5-(diaminomethylideneamino)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-2-[[2-[1-[2-oxo-2-[4-(6-oxo-5,11-dihydrobenzo[c][1]benzazepin-11-yl)piperazin-1-yl]ethyl]cyclopentyl]acetyl]amino]pentanamide;N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide;Cyclopentaneacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-
- CBNumber:
- CB9122491
- Molecular Formula:
- C49H57N11O6
- Molecular Weight:
- 896.05
- MDL Number:
- MFCD09878236
- MOL File:
- 246146-55-4.mol
- MSDS File:
- SDS
| Density | 1.38±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at +4°C |
| solubility | <67.2mg/ml in DMSO; <23.55mg/ml in ethanol |
| pka | 13.28±0.40(Predicted) |
| form | solid |
| color | White |
| FDA UNII | N3Z657H81X |
BIIE 0246 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B384503 | BIIE0246 | 246146-55-4 | 0.5mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-0022426 | BIIE-0246 >99.0% | 246146-55-4 | 1mg | $210 | 2021-12-16 | Buy |
| ApexBio Technology | B6836 | BIIE0246 | 246146-55-4 | 1mg | $251 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BIO0000364 | BIIE-0246 95.00% | 246146-55-4 | 5MG | $503.84 | 2021-12-16 | Buy |
BIIE 0246 Chemical Properties,Uses,Production
Uses
BIIE 0246, is a selective non-peptide antagonist which binds to the neuropeptide NPY2-R in a competitive manner. Studies have also shown that BIIE 0246 is highly lipophilic and as a result BIIE 0246 builds up at membranes near the receptors.
Biological Activity
Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y 2 receptor (IC 50 = 15 nM). Displays > 650-fold selectivity over Y 1 , Y 4 and Y 5 receptors. Active in vivo .
References
[1]. doods h, gaida w, wieland ha, et al. biie0246: a selective and high affinity neuropeptide y y(2) receptor antagonist. eur j pharmacol, 1999, 384(2-3): r3-5.
[2]. el bahh b, cao jq, beck-sickinger ag, et al. blockade of neuropeptide y(2) receptors and suppression of npy's anti-epileptic actions in the rat hippocampal slice by biie0246. br j pharmacol, 2002, 136(4): 502-509.
[3]. dumont y, cadieux a, doods h, et al. biie0246, a potent and highly selective non-peptide neuropeptide y y(2) receptor antagonist. br j pharmacol, 2000, 129(6): 1075-1088.
[4]. abbott cr, small cj, kennedy ar, et al. blockade of the neuropeptide y y2 receptor with the specific antagonist biie0246 attenuates the effect of endogenous and exogenous peptide yy(3-36) on food intake. brain res, 2005, 1043(1-2): 139-144.
[5]. bacchi f, mathé aa, jiménez p, et al. anxiolytic-like effect of the selective neuropeptide y y2 receptor antagonist biie0246 in the elevated plus-maze. peptides, 2006, 27(12): 3202-3207.
BIIE 0246 Preparation Products And Raw materials
Raw materials
Preparation Products
BIIE 0246 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 588 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24731 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 13774214275 | zhouzz@univ-bio.com | China | 24994 | 58 |
