nargenicin A1
- CAS No.
- 70695-02-2
- Chemical Name:
- nargenicin A1
- Synonyms
- CP-47444;NSC 355066;Antibiotic 47444;Antibiotic CP-47444;Nargenicin A1 DISCONTINUED;Nodusmicin 9-(1H-pyrrole-2-carboxylate);1H-Pyrrole-2-carboxylic acid, (1E,3R,4S,7S,8aS,10aR,11R,12R,13R,14R,14aS,14bS)-3,4,6,7,8,8a,10a,11,12,13,14,14a-dodecahydro-14-hydroxy-4-[(1R)-1-hydroxyethyl]-7-methoxy-1,3,13-trimethyl-6-oxo-11,14b-epoxy-14bH-naphth[2,1-e]oxecin-12-yl ester
- CBNumber:
- CB91343679
- Molecular Formula:
- C28H37NO8
- Molecular Weight:
- 515.599
- MDL Number:
- MFCD08702706
- MOL File:
- 70695-02-2.mol
| Boiling point | 718.3±60.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C,protect from light |
| solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble |
| form | Off-white powder. |
| pka | 14.03±0.20(Predicted) |
| color | Off-white |
| FDA UNII | XP2QP458K4 |
nargenicin A1 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25456 | Nargenicin ≥99% | 70695-02-2 | 1mg | $246 | 2024-03-01 | Buy |
| Cayman Chemical | 25456 | Nargenicin ≥99% | 70695-02-2 | 5mg | $738 | 2024-03-01 | Buy |
| Adipogen Life Sciences | BVT-0204-M001 | NargenicinA1 ≥98%(HPLC) | 70695-02-2 | 1mg | $190 | 2021-12-16 | Buy |
nargenicin A1 Chemical Properties,Uses,Production
Description
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. In murine BV-2 microglial cells, nargenicin (1 μM) inhibits cytokine expression and nitric oxide production induced by LPS. Nargenicin (200 μM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid , reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells. In vivo, nargenicin (50 mg/kg, p.o.) reduces the number of colony-forming units (CFUs) in infected kidneys by 100,000-fold in a murine model of S. aureus infection.
Uses
Nargenicin A1 is an antibiotic with a broad efficacy.
storage
+4°C
nargenicin A1 Preparation Products And Raw materials
Raw materials
Preparation Products
nargenicin A1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |