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Trimethyl orthobenzoate

Trimethyl orthobenzoate structure

CAS No.: 707-07-3

Chemical Name:: Trimethyl orthobenzoate

Synonyms: (Trimethoxymethyl)benzene;Methyl orthobenzoate;Benzene, (trimethoxymethyl)-;SKL283;NSC-67391;Orthobenzoate;trimethyl benzoate;TRIMETHYL-O-BENZOATE;Intedanib Impurity 6;Sunitinib Impurity 71

CBNumber:: CB9160297

Molecular Formula:: C10H14O3

Molecular Weight:: 182.22

MDL Number:: MFCD00008474

MOL File:: 707-07-3.mol

MSDS File:: SDS

Last updated:2024-03-13 16:52:01

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Trimethyl orthobenzoate Properties

Boiling point	87-88 °C/7 mmHg (lit.)
Density	1.061 g/mL at 25 °C (lit.)
refractive index	n20/D 1.489(lit.)
Flash point	180 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in organic solvents.
form	Liquid
color	Clear colorless
Sensitive	Moisture Sensitive
BRN	777623
Stability	Hygroscopic
InChIKey	IECKAVQTURBPON-UHFFFAOYSA-N
CAS DataBase Reference	707-07-3(CAS DataBase Reference)
FDA UNII	3755490344
NIST Chemistry Reference	Benzene, (trimethoxymethyl)-(707-07-3)
EPA Substance Registry System	Benzene, (trimethoxymethyl)- (707-07-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-37/39

WGK Germany

TSCA

Yes

HS Code

29163100

NFPA 704

	2
2		1

Trimethyl orthobenzoate price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	164534	Trimethyl orthobenzoate 98%	707-07-3	50g	$486	2024-03-01	Buy
Sigma-Aldrich	164534	Trimethyl orthobenzoate 98%	707-07-3	10g	$99.4	2023-06-20	Buy
TCI Chemical	T2287	Trimethyl Orthobenzoate >95.0%(GC)	707-07-3	5g	$18	2024-03-01	Buy
TCI Chemical	T2287	Trimethyl Orthobenzoate >95.0%(GC)	707-07-3	25g	$52	2024-03-01	Buy
Alfa Aesar	A10270	Trimethyl orthobenzoate, 98%	707-07-3	10g	$40.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
164534	50g	$486	Buy
164534	10g	$99.4	Buy
T2287	5g	$18	Buy
T2287	25g	$52	Buy
A10270	10g	$40.65	Buy

Trimethyl orthobenzoate Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Uses

Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1661, 1950 DOI: 10.1021/ja01160a067

General Description

Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide.

Trimethyl orthobenzoate synthesis

Synthesis of Trimethyl orthobenzoate from Benzonitrile

Trimethyl orthobenzoate Preparation Products And Raw materials

Raw materials

Tetramethoxymethane Benzenecarboximidic acid methyl ester N-methylbenzanilide

Preparation Products

Benzamide (E)-Methyl 1-acetyl-3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester tert-Butyl 4-oxo-2-phenyl-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate

Trimethyl orthobenzoate Suppliers

Global( 289)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hong Kong Excellence Biotechnology Co., Ltd.		ada@sh-teruiop.com	China	875	58
Sigma Audley	+86-15937194204 +86-18126314766	nova@sh-teruiop.com	China	467	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2964	58

Supplier	Advantage
Jinan Carbotang Biotech Co.,Ltd.	58
Hong Kong Excellence Biotechnology Co., Ltd.	58
Sigma Audley	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from Trimethyl orthobenzoate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-25	Trimethyl orthobenzoate 707-07-3	US $5.00 / kg	1kg	≥99%	211-897-5	Jinan Finer Chemical Co., Ltd
2024-09-19	Trimethyl orthobenzoate 707-07-3	US $100.00 / kg	1kg	99.9%	20tons	Hong Kong Excellence Biotechnology Co., Ltd.
2024-01-16	Trimethyl orthobenzoate 707-07-3	US $45.00-35.00 / kg	1kg	99.8%	200tons/year	Sigma Audley

Trimethyl orthobenzoate
707-07-3
US $5.00 / kg
≥99%
Jinan Finer Chemical Co., Ltd

Trimethyl orthobenzoate
707-07-3
US $100.00 / kg
99.9%
Hong Kong Excellence Biotechnology Co., Ltd.

Trimethyl orthobenzoate
707-07-3
US $45.00-35.00 / kg
99.8%
Sigma Audley

Trimethyl orthobenzoate Spectrum

Trimethyl orthobenzoate(707-07-3)MS Trimethyl orthobenzoate(707-07-3)¹HNMR Trimethyl orthobenzoate(707-07-3)¹³CNMR Trimethyl orthobenzoate(707-07-3)IR1 Trimethyl orthobenzoate(707-07-3)Raman

707-07-3(Trimethyl orthobenzoate)Related Search:

Trimethyl orthoacetate Methyl 2-bromobenzoate Methyl 4-cyanobenzoate Methyl 4-(bromomethyl)benzoate Trimethoxymethane

Methyl benzoate Methylparaben Methyl 4-methylbenzoate Trimethyl borate Triethyl orthobenzoate

Trimethyl orthopropionate Triethyl orthopropionate Trimethyl orthobutyrate TRIS(2-CHLOROETHYL)- ORTHOFORMATE Triphenylmethanol

TRIPHENYL PHOSPHOROTHIONATE ORTHODICHLOROACETIC ACID TRIETHYL ESTER Tripropyl orthoformate

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(trimethoxymethyl)-benzen Orthobenzoic acid, trimethyl ester à,à,à-trimethoxytoluene Thrimethyl orthobenzoate Phenylorthoformic acid trimethyl ester Phenyltrimethoxymethane Trimethoxyphenylmethane Trimethyl orthobenzoate,97% alpha,alpha,alpha-Trimethoxytoluene Orthobenzoic Acid Trimethyl Ester alpha,alpha,alpha-Trimethoxytoluene Methyl Orthobenzoate Trimethyl orthobenzoate 98% TRIMETHYL ORTHOBENZOATE TRIMETHYL-O-BENZOATE TriMethyl Orthobenzoate, 95%(GC) Orthobenzoate NSC-67391 Intedanib Impurity 6 Trimethyl Orthobenzoate Liquid trimethyl benzoate SKL283 Trimethyl orthobenzoate (Nintedanib Impurity) (Trimethoxymethyl)benzene Benzene, (trimethoxymethyl)- Methyl orthobenzoate Sunitinib Impurity 71 707-07-3 C6H5COCH33 Building Blocks Oxygen Compounds Organic Building Blocks Acetals/Ketals/Ortho Esters Acetals/Ketals/Ortho Esters Organic Building Blocks Oxygen Compounds bc0001 707-07-3