4-Hydroxycinnamic acid
- CAS No.
- 7400-08-0
- Chemical Name:
- 4-Hydroxycinnamic acid
- Synonyms
- 4-Hydroxycinnamic acid;P-HYDROXYCINNAMIC ACID;TRANS-4-COUMARIC ACID;TRANS-P-COUMARIC ACID;PHCA;P-CUMARIC ACID;TRANS-P-CUMARIC ACID;4-hydroxylcinnamic acid;3-(4-HYDROXYPHENYL)ACRYLIC ACID;3-(4-Hydroxyphenyl)propenoic acid
- CBNumber:
- CB9164396
- Molecular Formula:
- C9H8O3
- Molecular Weight:
- 164.16
- MDL Number:
- MFCD00004399
- MOL File:
- 7400-08-0.mol
- MSDS File:
- SDS
| Melting point | 214 °C (dec.)(lit.) |
|---|---|
| Boiling point | 251.61°C (rough estimate) |
| Density | 1.2132 (rough estimate) |
| refractive index | 1.5380 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) |
| pka | 4.65±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| biological source | rabbit |
| Stability | Light Sensitive |
| InChI | InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12) |
| InChIKey | NGSWKAQJJWESNS-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C=CC1=CC=C(O)C=C1 |
| LogP | 1.790 |
| CAS DataBase Reference | 7400-08-0(CAS DataBase Reference) |
| FDA UNII | IBS9D1EU3J |
| NIST Chemistry Reference | 2-Propenoic acid, 3-(4-hydroxyphenyl)-(7400-08-0) |
| EPA Substance Registry System | p-Hydroxycinnamic acid (7400-08-0) |
| UNSPSC Code | 12352203 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39-22 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | GD9095000 | |||||||||
| HS Code | 2918 29 00 | |||||||||
| NFPA 704 |
|
4-Hydroxycinnamic acid price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.00237 | 4-Hydroxycinnamic acid for synthesis | 7400-08-0 | 10g | $56.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB1303797 | ANTI-ACER3 (C-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 400μL | $481 | 2024-03-01 | Buy | |
| Sigma-Aldrich | 8.00237 | 4-Hydroxycinnamic acid for synthesis | 7400-08-0 | 50g | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB4502315 | Anti-PHCA antibody produced in rabbit affinity isolated antibody | 7400-08-0 | 100μG | $434 | 2022-05-15 | Buy |
| TRC | C755365 | p-Coumaric acid | 7400-08-0 | 250g | $275 | 2021-12-16 | Buy |
4-Hydroxycinnamic acid Chemical Properties,Uses,Production
Chemical Properties
Light yellow to beige crystalline powder with aroma, soluble in methanol, ethanol, DMSO and other organic solvents, derived from synthesis.
Uses
4-Hydroxycinnamic acid is the hydroxy derivative of Cinnamic Acid with antioxidant properties. It is a is a major component of lignocellulose. Studies suggest that 4-Hydroxycinnamic acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines. A recent study reports that 4-Hydroxycinnamic acid may act as a chemical castrator in bees by altering the epression of genes required for ovary development. This compound is common in pollen a major constituent of the worker bee diet, but it is not found in queen bees'royal jelly.
Application
p-Hydroxycinnamic acid is mainly used as an intermediate in the pharmaceutical and perfume industries. It can react with dimethyl sulfate to produce p-anisaldehyde, react with acetaldehyde to produce p-hydroxycinnamaldehyde, and further oxidize it to produce cinnamic acid. This product can be directly oxidized to produce 4-Hydroxybenzoic acid and reduction to produce 4-Hydroxybenzyl alcohol.
Definition
ChEBI: 4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate.
Hazard
Moderately toxic.
Safety Profile
Moderarely toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes. See also COUMARIN
4-Hydroxycinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | 1713330907@QQ.com | China | 2639 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9297 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3005 | 58 |
| Shandong Juchuang Chemical Co., LTD | +16837774622 | admin@juchuangchem.com | China | 295 | 58 |
| Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 | sales@richfortunechem.com | China | 304 | 57 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
Related articles
- 4-Hydroxycinnamic Acid: Dietary Sources, Pharmacokinetics and Biological Activities
- 4-Hydroxycinnamic acid, a bioavailable phenolic compound from dietary sources, provides antioxidant, antimicrobial and antican....
- Oct 11，2024
View Lastest Price from 4-Hydroxycinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-25 | 4-Hydroxycinnamic acid
7400-08-0
|
US $0.00-0.00 / kg | 1kg | 99%+ | 100000kg per Month | Shanghai Qyubiotech Co., Ltd. | |
 |
2025-04-23 | p-Hydroxy-cinnamic acid
7400-08-0
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | 4-Hydroxycinnamic acid
7400-08-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 4-Hydroxycinnamic acid
7400-08-0
- US $0.00-0.00 / kg
- 99%+
- Shanghai Qyubiotech Co., Ltd.
-
- p-Hydroxy-cinnamic acid
7400-08-0
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Hydroxycinnamic acid
7400-08-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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