(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
- CAS No.
- 17257-71-5
- Chemical Name:
- (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
- Synonyms
- (-)-MTPA;(S)-(-)-MPTA;MOSHERS ACID;(-)-MOSHER'S ACID;(S)-(-)-Mosheracid;(S)-(-)-MOSHER'S ACID;(-)-MTPA, Moshers acid;(-)-Moshers acid~(-)-MTPA;(S)-(-)-MTPA,(S)-(-)-Mosher'sacid;(-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
- CBNumber:
- CB9171585
- Molecular Formula:
- C10H9F3O3
- Molecular Weight:
- 234.17
- MDL Number:
- MFCD00064200
- MOL File:
- 17257-71-5.mol
- MSDS File:
- SDS
Melting point | 46-49 °C(lit.) |
---|---|
alpha | D24 -71.8± 0.6° (c = 3.28 in CH3OH) |
Boiling point | 95-97 °C0.05 mm Hg(lit.) |
Density | 1.303 g/mL at 25 °C(lit.) |
refractive index |
n |
Flash point | >230 °F |
storage temp. | 2-8°C |
solubility | Readily soluble in hexane, ether, THF, CH2Cl2, benzene. |
pka | 1.47±0.10(Predicted) |
form | Viscous Liquid or Low Melting Solid |
Specific Gravity | 1.303 |
color | Clear colorless or white |
optical activity | [α]20/D 73±1°, c = 2% in methanol |
Sensitive | Hygroscopic |
Merck | 14,6280 |
BRN | 3591561 |
CAS DataBase Reference | 17257-71-5(CAS DataBase Reference) |
FDA UNII | 172HCJ1IQV |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
WGK Germany | 3 | |||||||||
F | 3-10 | |||||||||
Hazard Note | Irritant/Keep Cold | |||||||||
HazardClass | IRRITANT, HYGROSCOPIC, KEEP COLD | |||||||||
HS Code | 29189900 | |||||||||
NFPA 704 |
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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 318035 | (S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid ≥99% | 17257-71-5 | 250mg | $80.1 | 2024-03-01 | Buy |
Sigma-Aldrich | 318035 | (S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid ≥99% | 17257-71-5 | 1g | $170 | 2024-03-01 | Buy |
Sigma-Aldrich | 65369 | (S)-(−)-α-Methoxy-α-trifluoromethylphenylacetic acid for chiral derivatization, LiChropur?, ≥99.0% | 17257-71-5 | 250mg | $162 | 2022-05-15 | Buy |
TCI Chemical | M0832 | (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T) | 17257-71-5 | 1g | $187 | 2024-03-01 | Buy |
TCI Chemical | M0832 | (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving] >98.0%(GC)(T) | 17257-71-5 | 5g | $693 | 2024-03-01 | Buy |
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
clear colorless viscous liquid
Uses
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.
General Description
(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.
Purification Methods
A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 17777 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5790 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30239 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49978 | 58 |
View Lastest Price from (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-02 | (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid >=99%
17257-71-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid >=99%
17257-71-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Spectrum
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