MPEP
- CAS No.
- 96206-92-7
- Chemical Name:
- MPEP
- Synonyms
- MPEP;CS-715;MPEP,HCl;MPEP 100MG;MPEP USP/EP/BP;MPEP HYDROCHLORIDE;2-methyl-6-(2-phenylethynyl)pyridine;Pyridine, 2-methyl-6-(2-phenylethynyl)-;6-METHYL-2-(PHENYLETHYNYL)-PYRIDINE HCL;2-METHYL-6-(PHENYLETHYNYL)PYRIDINE HYDROCHLORIDE
- CBNumber:
- CB9171767
- Molecular Formula:
- C14H11N
- Molecular Weight:
- 193.24
- MDL Number:
- MFCD03787983
- MOL File:
- 96206-92-7.mol
| Melting point | 45-45.5 °C |
|---|---|
| Boiling point | 124.5-126.5 °C(Press: 0.5 Torr) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Off-white powder. |
| pka | 2.97±0.12(Predicted) |
| color | White to Off-White |
| Stability | Light Sensitive |
| FDA UNII | 7VC0YVI27Y |
MPEP price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.04635 | MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem | 96206-92-7 | 10mg | $218 | 2022-05-15 | Buy |
| Tocris | 1212 | MPEPhydrochloride ≥99%(HPLC) | 96206-92-7 | 10 | $150 | 2021-12-16 | Buy |
| Tocris | 1212 | MPEPhydrochloride ≥99%(HPLC) | 96206-92-7 | 50 | $611 | 2021-12-16 | Buy |
| Usbiological | 255896 | MPEP hydrochloride | 96206-92-7 | 10mg | $403 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0076023 | MPEP 95.00% | 96206-92-7 | 0.5G | $682 | 2021-12-16 | Buy |
MPEP Chemical Properties,Uses,Production
Uses
2-Methyl-6-(2-phenylethynyl)pyridine induces pathophysiological mGluR5 signaling in Alzheimer''s disease model mice in sex-selective manner.
Uses
A potent, subtype selective mGluR5 antagonist
Uses
MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).
Definition
ChEBI: 2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.
Biological Activity
Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ .
References
[1] gasparini f, lingenhöhl k, stoehr n, et al. 2-methyl-6-(phenylethynyl)-pyridine (mpep), a potent, selective and systemically active mglu5 receptor antagonist. neuropharmacology, 1999, 38(10): 1493-1503.
[2] tatarczyńska e, kłodzińska a, chojnacka-wójcik e, et al. potential anxiolytic-and antidepressant-like effects of mpep, a potent, selective and systemically active mglu5 receptor antagonist. british journal of pharmacology, 2001, 132(7): 1423-1430.
MPEP Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from MPEP manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | MPEP
96206-92-7
|
US $40.00-139.00 / mg | 99.54% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-05 | Ifenprodil HeMitartrate
23210-58-4
|
US $0.00-0.00 / mg | 5ASSAYS | 99% HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- MPEP
96206-92-7
- US $40.00-139.00 / mg
- 99.54%
- TargetMol Chemicals Inc.
-
- Ifenprodil HeMitartrate
23210-58-4
- US $0.00-0.00 / mg
- 99% HPLC
- Shaanxi Dideu Medichem Co. Ltd