MEVINPHOS
- CAS No.
- 26718-65-0
- Chemical Name:
- MEVINPHOS
- Synonyms
- DURAPHOS;PHOSDRIN;MEVINPHOS;MEVINDRIN;OS-2046(R);E-MEVINPHOS;PHOSDRIN (TM);TRANS-MEVINPHOS;cis-Duraphos(TM);formerly 298-01-1
- CBNumber:
- CB9177587
- Molecular Formula:
- C7H13O6P
- Molecular Weight:
- 224.15
- MDL Number:
- MFCD00048060
- MOL File:
- 26718-65-0.mol
MEVINPHOS Chemical Properties,Uses,Production
Uses
Mevinphos is used to control chewing and sucking insects in a wide range of crops.
Definition
ChEBI: Mevinphos is a dialkyl phosphate and an organophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide, an agrochemical and an avicide. It is functionally related to a methyl 3-hydroxybut-2-enoate.
Metabolic pathway
Technical mevinphos consists of two stereochemical isomers in the E:Z ratio of about 7:3. Mevinphos is characterised by a high rate of metabolic breakdown, such that crops can be harvested within a few hours of its application. The compound is also rapidly translocated within plants. There are considerable differences in the metabolism of the two isomers. In general, the E-isomer (the more toxic, more active acetylcholinesterase inhibitor and more effective insecticide) is detoxified more quickly in plants but more slowly in animals. The major route of detoxification in plants is through hydrolysis to give dimethyl phosphate and methyl acetoacetate with hydrolysis of the carboxylic ester function being of lesser importance. Demethylation of the more toxic Eisomer via a glutathione-based transalkylation reaction is an important route in mammals, whereas the 2-isomer is hydrolysed to dimethyl phosphate .
Degradation
Mevinphos is hydrolysed in alkaline solutions (PM). The DT50s for the technical material at pH 6, 7 and 10 were 94 days, 30 days and 8 hours respectively (Porter et al., 1964). The E-isomer (1) is hydrolysed more quickly than the Z-isomer (2). Under alkaline conditions, the products of hydrolysis of the E-isomer were shown to be dimethyl phosphate (3), monomethyl phosphate (4), acetone (S), the E-mevinphos carboxylic acid (6) and the desmethyl E-mevinphos carboxylic acid (7). A small amount of desmethyl E-mevinphos (8) was also detected. The Z-isomer gave very little of the desmethyl Z-mevinphos carboxylic acid (10) indicating that the attack of hydroxyl ion on the 2-isomer was almost entirely on phosphorus, whereas there was additional nucleophilic attack on the carboxylic ester function in the case of the E-isomer which was shown to gwe dimethyl phosphate (3) and acetone (5). Acid hydrolysis resulted in demethylation of both isomers with the desmethyl E-mevinphos (8) and desmethyl Z-mevinphos (9) being detected in addition to dimethyl phosphate (3) and monomethyl phosphate (4) (Spencer et al., 1958) (see Scheme 1).
MEVINPHOS Preparation Products And Raw materials
Raw materials
Preparation Products
MEVINPHOS Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | sales@senfeida.com | China | 23048 | 58 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9303 | 58 |
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