Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether

2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether

2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether Structure
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether structure
CAS No.
652142-94-4
Chemical Name:
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether
Synonyms
STING Agonist 1a;2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether
CBNumber:
CB91902720
Molecular Formula:
C19H11Cl2N5O
Molecular Weight:
396.22954
MDL Number:
MOL File:
652142-94-4.mol
Last updated:2024-07-02 08:55:41
Request For Quotation

2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether Properties

storage temp. Store at -20°C
solubility DMF: slightly soluble,DMSO: slightly soluble,PBS (pH 7.2): slightly soluble
form A crystalline solid
color Off-white to light brown

2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether Chemical Properties,Uses,Production

Biological Activity

STING agonist 1a is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

References

1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)

2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Changzhou Furuisi Biotechnology Co., Ltd 58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether STING Agonist 1a 652142-94-4 C19H11Cl2N5O