Alacepril
- CAS No.
- 74258-86-9
- Chemical Name:
- Alacepril
- Synonyms
- du1219;Alapri;cetapril;Cetapfil;ALACEPRIL;Alacepril API;(s)-l-phenylalanin;Alacepril USP/EP/BP;Alacepril, 10 mM in DMSO;N-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH
- CBNumber:
- CB9198959
- Molecular Formula:
- C20H26N2O5S
- Molecular Weight:
- 406.5
- MDL Number:
- MFCD00869538
- MOL File:
- 74258-86-9.mol
- MSDS File:
- SDS
| Melting point | 155-156° |
|---|---|
| alpha | D25 -81.3° (c = 1.02 in ethanol) |
| Boiling point | 679.1±55.0 °C(Predicted) |
| Density | 1.281±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 3.56±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| CAS DataBase Reference | 74258-86-9(CAS DataBase Reference) |
| FDA UNII | X39TL7JDPF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Toxicity | LD50 in rats, mice (mg/kg): >5000, >5000 orally; >3000, >3000 s.c.; ~2000, ~3000 i.p. (Iida, pp 7033-40) |
Alacepril price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FA158541 | Alacepril | 74258-86-9 | 10mg | $120 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0001937 | ALACEPRIL 95.00% | 74258-86-9 | 1MG | $152.25 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA158541 | Alacepril | 74258-86-9 | 1mg | $40 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0001937 | ALACEPRIL 95.00% | 74258-86-9 | 1G | $1428 | 2021-12-16 | Buy |
| Arctom | AS566841 | Alacepril ≥95% | 74258-86-9 | 5mg | $44 | 2021-12-16 | Buy |
Alacepril Chemical Properties,Uses,Production
Description
Alacepril is an angiotensin-converting enzyme (ACE) inhibitor useful in the treatment of essential and renal hypertension. Compared with captopril, alacepril is a weaker ACE inhibitor in vino, yet clinically it has a longer duration of action and appears to be more active due to an added component of norepinephrine antagonism.
Originator
Dainippon (Japan)
Definition
ChEBI: Alacepril is a thioacetate ester and a dipeptide. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor.
Manufacturing Process
N-Methylmorpholine (1.03 g) was added to a solution of 1-(D-3-acetylthio-2-
methylpropanoyl)-L-proline (2.65 g) in dry tetrahydrofuran (50 ml). The
resulting solution was stirred and cooled at -20° to -15°C. Phenyl
chloroformate (1.61 g) was added, and after 5 min, a solution of Lphenylalanine
t-butyl ester hydrochloride (2.4 g) and N-methylmorpholine
(1.03 g) in dry tetrahydrofuran (30 ml) was added. The mixture was stirred at
-20° to -15°C for 1 h and then at room temperature overnight.
After removal of insoluble materials by filtration, the filtrate was concentrated
under reduced pressure and the residue was dissolved in chloroform.
The chloroform solution was washed successively with 1 N sodium hydroxide,
water, 10% citric acid, and water, dried and concentrated under reduced
pressure. The residue was chromatographed on silica gel with chloroformmethanol
(99:1) to give 4.2 g the 1-(D-3-acetylthio-2-methylpropanoyl)-Lprolyl-
L-phenylalanine tert-butyl ester.
1-(D-3-Acetylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanine tert-butyl ester (2.5 g) was dissolved in a mixture of anisole (18 ml) and trifluoroacetic acid
(37 ml). The solution was allowed to stand at room temperature for 1 h and
then concentrated to dryness under reduced pressure. The residue was
crystallized from diethyl ether. The 1-(D-3-acetylthio-2-methylpropanoyl)-Lprolyl-
L-phenylalanine was obtained (1.8 g), melting point 155°-156°C
(recrystallization from ethanol/n-hexane).
brand name
Cetapril
Therapeutic Function
Antihypertensive
Alacepril Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7859 | 58 |
| Shijiazhuang Gantuo Biotechnology Co., Ltd | +8613373514458 | gantuo02@cngantuo.com | China | 203 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38636 | 58 | |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3512 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
View Lastest Price from Alacepril manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Alacepril
74258-86-9
|
US $50.00-122.00 / mg | 98.19% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-06-26 | Alacepril
74258-86-9
|
US $200.00 / kg | 1kg | 99% | 1000kg/Month | Hebei Mingeng Biotechnology Co., Ltd | |
 |
2023-04-11 | Alacepril
74258-86-9
|
US $100.00 / KG | 1KG | 99% | 1000 Kilogram/Kilograms per Week | Shijiazhuang Gantuo Biotechnology Co., Ltd |