ChemicalBook >> CAS DataBase List >>1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE
- CAS No.
- 338773-13-0
- Chemical Name:
- 1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE
- Synonyms
- R-8507;R8507,R 8507;1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE;[1,2,4]Triazolo[4,3-a]quinoxaline, 1-(4-chlorophenyl)-4-(trifluoromethyl)-
- CBNumber:
- CB9238349
- Molecular Formula:
- C16H8ClF3N4
- Molecular Weight:
- 348.71
- MDL Number:
- MFCD00974644
- MOL File:
- Mol file
Last updated:2023-05-21 10:59:17
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 22479 | R-8507 ≥98% | 338773-13-0 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 22479 | R-8507 ≥98% | 338773-13-0 | 5mg | $169 | 2024-03-01 | Buy |
Cayman Chemical | 22479 | R-8507 ≥98% | 338773-13-0 | 10mg | $319 | 2024-03-01 | Buy |
Cayman Chemical | 22479 | R-8507 ≥98% | 338773-13-0 | 25mg | $704 | 2024-03-01 | Buy |
AK Scientific | 8160CE | 1-(4-Chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline | 338773-13-0 | 5mg | $286 | 2021-12-16 | Buy |
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE Chemical Properties,Uses,Production
Description
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).1 It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
References
1. Gururaja, T.L., Yung, S., Ding, R., et al. A class of small molecules that inhibit TNFα-
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE Suppliers
Global( 9)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE
R-8507
R8507,R 8507
[1,2,4]Triazolo[4,3-a]quinoxaline, 1-(4-chlorophenyl)-4-(trifluoromethyl)-
338773-13-0