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ChemicalBook >> CAS DataBase List >>1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE

1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE

1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE Structure
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE structure
CAS No.
338773-13-0
Chemical Name:
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE
Synonyms
R-8507;R8507,R 8507;1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE;[1,2,4]Triazolo[4,3-a]quinoxaline, 1-(4-chlorophenyl)-4-(trifluoromethyl)-
CBNumber:
CB9238349
Molecular Formula:
C16H8ClF3N4
Molecular Weight:
348.71
MDL Number:
MFCD00974644
MOL File:
Mol file
Last updated:2023-05-21 10:59:17
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1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE Properties

Density 1.55±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 2 mg/ml
form A crystalline solid
pka -2.21±0.40(Predicted)

1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22479 R-8507 ≥98% 338773-13-0 1mg $37 2024-03-01 Buy
Cayman Chemical 22479 R-8507 ≥98% 338773-13-0 5mg $169 2024-03-01 Buy
Cayman Chemical 22479 R-8507 ≥98% 338773-13-0 10mg $319 2024-03-01 Buy
Cayman Chemical 22479 R-8507 ≥98% 338773-13-0 25mg $704 2024-03-01 Buy
AK Scientific 8160CE 1-(4-Chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline 338773-13-0 5mg $286 2021-12-16 Buy
Product number Packaging Price Buy
22479 1mg $37 Buy
22479 5mg $169 Buy
22479 10mg $319 Buy
22479 25mg $704 Buy
8160CE 5mg $286 Buy

1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE Chemical Properties,Uses,Production

Description

R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).1 It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.

References

1. Gururaja, T.L., Yung, S., Ding, R., et al. A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1 Chem. Biol. 14(10),1105-1118(2007).

1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
1-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE R-8507 R8507,R 8507 [1,2,4]Triazolo[4,3-a]quinoxaline, 1-(4-chlorophenyl)-4-(trifluoromethyl)- 338773-13-0