SIRT1 ACTIVATOR 3
- CAS No.
- 839699-72-8
- Chemical Name:
- SIRT1 ACTIVATOR 3
- Synonyms
- CAY10591;SIRT1 ACTIVATOR 3;CAY10591 Exclusive;SIRTUIN 1 ACTIVATOR 3;1H-Pyrrolo[2,3-b]quinoxaline-3-carboxamide, 2-amino-N-cyclopentyl-1-(3-methoxypropyl)-
- CBNumber:
- CB92448234
- Molecular Formula:
- C20H25N5O2
- Molecular Weight:
- 367.44
- MDL Number:
- MFCD03692733
- MOL File:
- 839699-72-8.mol
SIRT1 ACTIVATOR 3 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10009797 | CAY10591 ≥98% | 839699-72-8 | 1mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 10009797 | CAY10591 ≥98% | 839699-72-8 | 5mg | $280 | 2024-03-01 | Buy |
| Cayman Chemical | 10009797 | CAY10591 ≥98% | 839699-72-8 | 10mg | $497 | 2024-03-01 | Buy |
| Cayman Chemical | 10009797 | CAY10591 ≥98% | 839699-72-8 | 25mg | $1084 | 2024-03-01 | Buy |
| TRC | S487903 | CAY10591 | 839699-72-8 | 2.5mg | $175 | 2021-12-16 | Buy |
SIRT1 ACTIVATOR 3 Chemical Properties,Uses,Production
Description
SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells.1 SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice.2 SirtAct inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients.3 Prevents and cures experimental colitis in a mouse model.3
Uses
SIRT1 Activator 3 is a SIRT1 activator which also inhibits TNF-α.
Definition
ChEBI: CAY10591 is a quinoxaline derivative.
References
1) Nayagam et al. (2006), SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin sensitizing agents; J. Biomol. Screen., 11 959 2) Barbieri et al. (2012), Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner; Circulation, 126 1373 3) Caruso et al. (2014), Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut; Mucosal Immunol., May 21 Epub.
SIRT1 ACTIVATOR 3 Preparation Products And Raw materials
Raw materials
Preparation Products
SIRT1 ACTIVATOR 3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |