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ChemicalBook >> CAS DataBase List >>5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Structure
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester structure
CAS No.
3543-74-6
Chemical Name:
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
Synonyms
Bendamustine USP RC C;Bendamustine Impurity 40;Bendamustine Dihydroxy Ester;Bendamustine Related Impurity 1;Bendamustine Related Compound C;Bendamustine USP Related Compound C;5-[Bis(2-hydroxyethyl)amino]-1-meth;ethyl 4-(5-(bis(2-hydroxyethyl)amino);Bendamustine hydrochloride Intermediates 1;Bendamustine USP RC C /Bendamustine Impurity A
CBNumber:
CB92485093
Molecular Formula:
C18H27N3O4
Molecular Weight:
349.42
MDL Number:
MFCD09840918
MOL File:
3543-74-6.mol
MSDS File:
SDS
Last updated:2024-03-28 13:39:29
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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Properties

Melting point 98-101°C
Boiling point 580.6±50.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.26±0.10(Predicted)
color White to Brown
FDA UNII AUL5NUY9I0

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H341-H351-H361fd
Precautionary statements  P201-P202-P264-P270-P280-P301+P310
HS Code  2933998350

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1065254 Bendamustine Related Compound C United States Pharmacopeia (USP) Reference Standard 3543-74-6 20MG $3470 2024-03-01 Buy
TRC M294190 [1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoicAcidEthylEster 3543-74-6 500mg $275 2021-12-16 Buy
AK Scientific J97550 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoicacidethylester 3543-74-6 5g $210 2021-12-16 Buy
AK Scientific J11386 BendamustineImpurity1 3543-74-6 25mg $49 2021-12-16 Buy
AK Scientific J11386 BendamustineImpurity1 3543-74-6 100mg $148 2021-12-16 Buy
Product number Packaging Price Buy
1065254 20MG $3470 Buy
M294190 500mg $275 Buy
J97550 5g $210 Buy
J11386 25mg $49 Buy
J11386 100mg $148 Buy

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Uses,Production

Chemical Properties

Off-White to Light Tan Solid

Uses

[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis.

Synthesis

Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%. 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester synthesis

75-21-8
3543-73-5
3543-74-6
Synthesis of 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester from ETHYLENE OXIDE and 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials

Raw materials

2,2'-[[4-(methylamino)-3-nitrophenyl]imino]bisethanol 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-hydroxyethyl)amino]-2,3-dihydro-2-hydroxy-1-methyl- oxirene 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid Pentanoic acid, 5-[(2-fluoro-5-nitrophenyl)amino]-5-oxo-
2-Fluoro-5-nitroaniline 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 1-Methyl-5-nitro-2-benzimidazolebutyric acid 2,2'-[(4-fluoro-3-nitrophenyl)imino]bisethanol 1-Methyl-5-nitro-1H-benzimidazole-2-butanoic Acid Ethyl Ester
ETHYLENE OXIDE 2-Bromoethanol Ethanol

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Preparation Products

Bendamustine hydrochloride

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Suppliers

Global( 184)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20274 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29793 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18750 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 8778 55
Lianyungang happen teng technology co., LTD 		15950718863 wang666xt@163.com CHINA 295 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 923 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Lianyungang happen teng technology co., LTD 		58
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Xiamen AmoyChem Co., Ltd 		58

View Lastest Price from 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester pictures 2024-03-29 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
3543-74-6
 US $32.00-1.30 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester pictures 2019-07-06 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
3543-74-6
 US $1.00 / KG 1KG 99% Customized Career Henan Chemical Co

3543-74-6(5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester)Related Search:

Bendamustine Impurity 26 FMOC-GLY-GLY-GLY-OH BEPOTASTINE BESILATE 5-alpha-Hydroxy- Laxogenin 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate Bendamustine Desmethyl Impurity Bendamustine Ether Impurity Bendamustine Impurity 28 DesMethyl BendaMustine Hydrochloride
BendaMustine IMpurity B 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Bendamustine Impurity 8 Bendamustine Impurity D 5-[bis-(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
Bendamustine Impurity 14 BendaMustine IMpurity C　　 5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid

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Ethyl-4-(5-(bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoate 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-2-benziMidazolebutyric Acid Ethyl Ester 4-[5-[Bis(2-hydroxyethyl)aMino]-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester ethyl 4-{5-[bis(2-hydroxyethyl)aMino]-1-Methyl-1H-1,3-benzodiazol-2-yl}butanoate Bendamustine Related Impurity 1 1H-Benzimidazole-2-butanoicacid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl ester 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acidethylester 1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester 5-(bis(2-hydroxyethyl)amino)-1-methyl-1h-benzimidazole-2-butanoic acid ethyl est Bendamustine hydrochloride Intermediates 1 Bendamustine Dihydroxy Ester [1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester Bendamustine Related ethyl 4-(5-(bis(2-hydroxyethyl)amino) Bendamustine USP RC C Bendamustine USP Related Compound C Ethyl 4-(5-Bis(2-Hydroxy Ethyl)Amino-1-Methyl-1Hbenzo[D]Imidazole-2-Yl]Butanoate 5-[Bis(2-hydroxyethyl)amino]-1-meth Bendamustine Impurity 40 Bendamustine Related Compound C Bendamustine USP RC C /Bendamustine Impurity A [1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butano... 5-112-hydroxyethyl complex with -1-methyl-1H benzimizole-2-butyrate B chisel Ethyl 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyrate Bendamustin Impurity-A (USP related compound C) 1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester 3543-74-6 543-74-6 intermediate Aromatics Intermediates & Fine Chemicals Pharmaceuticals