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YM155

YM155 Structure
YM155 structure
CAS No.
781661-94-7
Chemical Name:
YM155
Synonyms
M155;YM155;CS-35;YM155, >=98%;Sepantronium;YM-155;YM 155;YM155 USP/EP/BP;SepantroniuM broMide;Survivin Inhibitor YM155;YM155 (SepantroniuM BroMide)
CBNumber:
CB92506237
Molecular Formula:
C20H19BrN4O3
Molecular Weight:
443.29386
MDL Number:
MFCD11983133
MOL File:
781661-94-7.mol
Last updated:2024-11-19 23:02:33
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YM155 Properties

Melting point >180°C (dec.)
storage temp. -20°
solubility Soluble in DMSO (up to 25 mg/ml).
form solid
color Tan to yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA UNII 7H5Q4J1CM5
NCI Drug Dictionary sepantronium bromide

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29339900

YM155 price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 574662 Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin. 781661-94-7 10MG $155 2022-05-15 Buy
Cayman Chemical 11490 YM-155 ≥98% 781661-94-7 1mg $36 2024-03-01 Buy
Cayman Chemical 11490 YM-155 ≥98% 781661-94-7 5mg $70 2024-03-01 Buy
Cayman Chemical 11490 YM-155 ≥98% 781661-94-7 10mg $120 2024-03-01 Buy
Cayman Chemical 11490 YM-155 ≥98% 781661-94-7 25mg $257 2024-03-01 Buy
Product number Packaging Price Buy
574662 10MG $155 Buy
11490 1mg $36 Buy
11490 5mg $70 Buy
11490 10mg $120 Buy
11490 25mg $257 Buy

YM155 Chemical Properties,Uses,Production

Description

YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1?Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2?Induces DNA damage.3?YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4

Uses

YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.

Uses

YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC. cell lines. Potent Survivin Inhibitor.

Definition

ChEBI: Sepantronium bromide is an organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis. It has a role as an antineoplastic agent, a survivin suppressant and an apoptosis inducer. It contains a sepantronium.

target

Survivin

storage

Store at -20°C

References

1) Nakahara?et al. (2007),?YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res.?67?8014 2) Okamoto?et al. (2012),?Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther.?11?204 3) Glaros?et al. (2012),?The ‘survivin suppressants’ NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother. Pharmacol.?70?207 4) Wang?et al. (2014),?Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis?19?748

YM155 Preparation Products And Raw materials

Raw materials

Preparation Products

YM155 Suppliers

Global( 145)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hunan Jibang Biological Technology Co., LTD 		+8613776644403 sales02@kingboomtech.com China 1804 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Hunan Jibang Biological Technology Co., LTD 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from YM155 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sepantronium bromide pictures 2024-11-19 Sepantronium bromide
781661-94-7
 US $33.00-72.00 / mg 99.82% 10g TargetMol Chemicals Inc.
YM155 pictures 2020-01-13 YM155
781661-94-7
 US $3.00 / KG 1KG 98% 200KG Career Henan Chemical Co
  • YM155 pictures
  • YM155
    781661-94-7
  • US $3.00 / KG
  • 98%
  • Career Henan Chemical Co

YM155 Spectrum

YM155(781661-94-7)1HNMR

781661-94-7(YM155)Related Search:

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1of4

YM155 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide SepantroniuM broMide SepantroniuM broMide(YM155,YM-155) Sepantronium Bromide (YM155) 1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1) 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide YM 155 YM 155 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide Sepantronium YM155 (SepantroniuM BroMide) YM155, >=98% 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide YM155 (SEPANTRONIUM BROMIDE);YM-155 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidaz YM-155;YM 155 CS-35 3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione 3-(2-Methoxy-ethyl)-2-methyl-4,9-dioxo-1-pyrazin-2-ylmethyl-2,3,4,9-tetrahydro-1H-naphtho[2,3-d]imidazol-1-ium YM155, 98%, a novel small molecule survivin suppressant 3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(pyrazin-2-ylmethyl)naphtho[2,3-d]imidazol-1-ium bromide YM155 USP/EP/BP 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione,bromide M155 Survivin Inhibitor YM155 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide 781661-94-7 C20H19N4O3Br Inhibitors Antineoplastic apis Inhibitor