ChemicalBook >> CAS DataBase List >>(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
- CAS No.
- 179386-44-8
- Chemical Name:
- (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
- Synonyms
- CS-414;U95666E;PNU 95666;PNU 95666E;PNU-95,666 maleate;Sumanirole maleate;PubChem ID: 9818478;CID 9818479 maleate;U 95666E(Sumanirole maleate);Sumanirole maleate >=98% (HPLC)
- CBNumber:
- CB92510117
- Molecular Formula:
- C15H17N3O5
- Molecular Weight:
- 319.32
- MDL Number:
- MFCD09832637
- MOL File:
- 179386-44-8.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Properties
Melting point | 200-208°C (dec.) |
---|---|
storage temp. | -20°C |
solubility | H2O: soluble10mg/mL, clear |
form | powder |
color | white to beige |
optical activity | [α]/D -22 to -32°, c = 1 in H2O |
FDA UNII | 2OI87T3R1B |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1087 | Sumanirole maleate ≥98% (HPLC) | 179386-44-8 | 5mg | $115 | 2024-03-01 | Buy |
Sigma-Aldrich | SML1087 | Sumanirole maleate ≥98% (HPLC) | 179386-44-8 | 25mg | $184.8 | 2024-03-01 | Buy |
Sigma-Aldrich | 5.05896 | Sumanirole Maleate - CAS 179386-44-8 - Calbiochem | 179386-44-8 | 5mg | $191 | 2024-03-01 | Buy |
Cayman Chemical | 11984 | Sumanirole (maleate) ≥98% | 179386-44-8 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 11984 | Sumanirole (maleate) ≥98% | 179386-44-8 | 5mg | $100 | 2024-03-01 | Buy |
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Chemical Properties,Uses,Production
Uses
Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000).
Biochem/physiol Actions
Sumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson′s disease.
storage
Store at -20°C
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Suppliers
Global( 55)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49403 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40067 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6008 | 61 |
Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 19169 | 64 |
Shanghai Holy Biohemdeviser Co., Ltd | 021-61551100 | China | 444 | 57 | |
NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 |
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
PNU 95666
Sumanirole maleate
U 95666E(Sumanirole maleate)
U95666E
PNU 95666E
(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate
CID 9818479 maleate
PNU-95,666 maleate
PubChem ID: 9818478
(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate (1:1)
CS-414
U95666E;PNU 95666;PNU 95666E;SUMANIROLE
Sumanirole maleate >=98% (HPLC)
179386-44-8
C11H13N3OC4H4O4