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ChemicalBook >> CAS DataBase List >>(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Structure
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate structure
CAS No.
179386-44-8
Chemical Name:
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
Synonyms
CS-414;U95666E;PNU 95666;PNU 95666E;PNU-95,666 maleate;Sumanirole maleate;PubChem ID: 9818478;CID 9818479 maleate;U 95666E(Sumanirole maleate);Sumanirole maleate >=98% (HPLC)
CBNumber:
CB92510117
Molecular Formula:
C15H17N3O5
Molecular Weight:
319.32
MDL Number:
MFCD09832637
MOL File:
179386-44-8.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Properties

Melting point 200-208°C (dec.)
storage temp. -20°C
solubility H2O: soluble10mg/mL, clear
form powder
color white to beige
optical activity [α]/D -22 to -32°, c = 1 in H2O
FDA UNII 2OI87T3R1B

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1087 Sumanirole maleate ≥98% (HPLC) 179386-44-8 5mg $115 2024-03-01 Buy
Sigma-Aldrich SML1087 Sumanirole maleate ≥98% (HPLC) 179386-44-8 25mg $184.8 2024-03-01 Buy
Sigma-Aldrich 5.05896 Sumanirole Maleate - CAS 179386-44-8 - Calbiochem 179386-44-8 5mg $191 2024-03-01 Buy
Cayman Chemical 11984 Sumanirole (maleate) ≥98% 179386-44-8 1mg $32 2024-03-01 Buy
Cayman Chemical 11984 Sumanirole (maleate) ≥98% 179386-44-8 5mg $100 2024-03-01 Buy
Product number Packaging Price Buy
SML1087 5mg $115 Buy
SML1087 25mg $184.8 Buy
5.05896 5mg $191 Buy
11984 1mg $32 Buy
11984 5mg $100 Buy

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Chemical Properties,Uses,Production

Uses

Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000).

Biochem/physiol Actions

Sumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson′s disease.

storage

Store at -20°C

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49391 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30253 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33350 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6008 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070 info@chemlin.com.cn China 18077 64
Shanghai Holy Biohemdeviser Co., Ltd 021-61551100 China 444 57
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1494 55
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9900 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
Career Henan Chemica Co 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Chembest Research Laboratories Limited 61
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Holy Biohemdeviser Co., Ltd 57
NCE Biomedical Co.,Ltd. 55
Shanghai T&W Pharmaceutical Co., Ltd. 58
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate PNU 95666 Sumanirole maleate U 95666E(Sumanirole maleate) U95666E PNU 95666E (5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate CID 9818479 maleate PNU-95,666 maleate PubChem ID: 9818478 (5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate (1:1) CS-414 U95666E;PNU 95666;PNU 95666E;SUMANIROLE Sumanirole maleate >=98% (HPLC) 179386-44-8 C11H13N3OC4H4O4