ChemicalBook >> CAS DataBase List >>[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester
![[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Structure](CAS/GIF/353280-43-0.gif)
- CAS No.
- 353280-43-0
- Chemical Name:
- [[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester
- Synonyms
- S26948;S26948,S-26948;S 26948 >=98% (HPLC);[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester;2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester;Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-, 1,3-dimethyl ester
- CBNumber:
- CB92518890
- Molecular Formula:
- C28H25NO7S
- Molecular Weight:
- 519.57
- MDL Number:
- MFCD18086885
- MOL File:
- 353280-43-0.mol
Last updated:2025-01-27 09:38:02
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Properties
| Melting point | 65-67 °C(Solv: methanol (67-56-1)) |
|---|---|
| Boiling point | 687.3±65.0 °C(Predicted) |
| Density | 1.312±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO: soluble10mg/mL (clear solution) |
| form | powder |
| pka | 12.48±0.59(Predicted) |
| color | white to beige |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0510 | S 26948 ≥98% (HPLC) | 353280-43-0 | 5mg | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0510 | S 26948 ≥98% (HPLC) | 353280-43-0 | 25mg | $568 | 2024-03-01 | Buy |
| Cayman Chemical | 29722 | S 26948 | 353280-43-0 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 29722 | S 26948 | 353280-43-0 | 5mg | $140 | 2024-03-01 | Buy |
| TRC | S960015 | S 26948 | 353280-43-0 | 50mg | $875 | 2021-12-16 | Buy |
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Chemical Properties,Uses,Production
Description
S26948 is a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 8.83 nM in a transactivation assay). It is selective for PPARγ over PPARα, PPARβ/δ, and retinoid X receptor α (RXRα) at 10 μM. S26948 (30 mg/kg per day) decreases serum levels of glucose, triglycerides, non-esterified fatty acids, and insulin and increases hepatic palmitate oxidation in an ob/ob mouse model of type 2 diabetes. It decreases plasma levels of triglycerides and total and non-HDL cholesterol and the surface area of atherosclerotic lesions in the aortic sinus in an E2-KI transgenic mouse model of dyslipidemia and atherosclerosis fed a Western diet when administered at a dose of 30 mg/kg.
Uses
S26948 is a peroxisome proliferator-activated receptor γ modulator with potent antidiabetes and antiatherogenic effects.
Synthesis of [[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester from Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methylene]-, 1,3-dimethyl ester
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Preparation Products And Raw materials
Raw materials
Preparation Products
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Suppliers
Global( 17)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester
2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester
S26948
S 26948 >=98% (HPLC)
S26948,S-26948
Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-, 1,3-dimethyl ester
353280-43-0
C28H25NO7S