[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester

CAS No.
353280-43-0
Chemical Name:
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester
Synonyms
S26948;S26948,S-26948;S 26948 >=98% (HPLC);[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester;2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester;Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-, 1,3-dimethyl ester
CBNumber:
CB92518890
Molecular Formula:
C28H25NO7S
Molecular Weight:
519.57
MDL Number:
MFCD18086885
MOL File:
353280-43-0.mol
Last updated:2023-07-16 08:27:59

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Properties

Melting point 65-67 °C(Solv: methanol (67-56-1))
Boiling point 687.3±65.0 °C(Predicted)
Density 1.312±0.06 g/cm3(Predicted)
storage temp. Store at RT
solubility DMSO: soluble10mg/mL (clear solution)
form powder
pka 12.48±0.59(Predicted)
color white to beige

SAFETY

Risk and Safety Statements

WGK Germany  3

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0510 S 26948 ≥98% (HPLC) 353280-43-0 5mg $144 2024-03-01 Buy
Sigma-Aldrich SML0510 S 26948 ≥98% (HPLC) 353280-43-0 25mg $568 2024-03-01 Buy
Cayman Chemical 29722 S 26948 353280-43-0 1mg $44 2024-03-01 Buy
Cayman Chemical 29722 S 26948 353280-43-0 5mg $140 2024-03-01 Buy
TRC S960015 S 26948 353280-43-0 50mg $875 2021-12-16 Buy
Product number Packaging Price Buy
SML0510 5mg $144 Buy
SML0510 25mg $568 Buy
29722 1mg $44 Buy
29722 5mg $140 Buy
S960015 50mg $875 Buy

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Chemical Properties,Uses,Production

Description

S26948 is a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 8.83 nM in a transactivation assay). It is selective for PPARγ over PPARα, PPARβ/δ, and retinoid X receptor α (RXRα) at 10 μM. S26948 (30 mg/kg per day) decreases serum levels of glucose, triglycerides, non-esterified fatty acids, and insulin and increases hepatic palmitate oxidation in an ob/ob mouse model of type 2 diabetes. It decreases plasma levels of triglycerides and total and non-HDL cholesterol and the surface area of atherosclerotic lesions in the aortic sinus in an E2-KI transgenic mouse model of dyslipidemia and atherosclerosis fed a Western diet when administered at a dose of 30 mg/kg.

Uses

S26948 is a peroxisome proliferator-activated receptor γ modulator with potent antidiabetes and antiatherogenic effects.

353280-40-7
353280-43-0
Synthesis of [[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester from Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methylene]-, 1,3-dimethyl ester

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Preparation Products And Raw materials

Raw materials

Preparation Products

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester 2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester S26948 S 26948 >=98% (HPLC) S26948,S-26948 Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-, 1,3-dimethyl ester 353280-43-0 C28H25NO7S