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10(S),17(S)-DiHDoHE

10(S),17(S)-DiHDoHE Structure
10(S),17(S)-DiHDoHE structure
CAS No.
871826-47-0
Chemical Name:
10(S),17(S)-DiHDoHE
Synonyms
10(S),17(S)-DiHDHA;10(S),17(S)-DiHDoHE;10(S),17(S)-DiHDoHE Exclusive;4,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, (4Z,7Z,10S,11E,13Z,15E,17S,19Z)-
CBNumber:
CB92589838
Molecular Formula:
C22H32O4
Molecular Weight:
360.487
MDL Number:
MFCD18427937
MOL File:
871826-47-0.mol
Last updated:2024-07-02 08:55:41
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10(S),17(S)-DiHDoHE Properties

storage temp. Store at -20°C
solubility 0.1 M Na2CO3: 1 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.5 mg/ml
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Danger
Hazard statements  H225
Precautionary statements  P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
NFPA 704
3
0 0

10(S),17(S)-DiHDoHE price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10008128 10(S),17(S)-DiHDHA ≥98% 871826-47-0 25μg $182 2024-03-01 Buy
Cayman Chemical 10008128 10(S),17(S)-DiHDHA ≥98% 871826-47-0 50μg $324 2024-03-01 Buy
Cayman Chemical 10008128 10(S),17(S)-DiHDHA ≥98% 871826-47-0 100μg $612 2024-03-01 Buy
American Custom Chemicals Corporation CCH0004485 10(S),17(S)-DIHYDROXY-4Z,7Z,11E,13Z,15E,19Z-DOCOSAHEXAENOIC ACID 95.00% 871826-47-0 1MG $721.88 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004485 10(S),17(S)-DIHYDROXY-4Z,7Z,11E,13Z,15E,19Z-DOCOSAHEXAENOIC ACID 95.00% 871826-47-0 10MG $1732.5 2021-12-16 Buy
Product number Packaging Price Buy
10008128 25μg $182 Buy
10008128 50μg $324 Buy
10008128 100μg $612 Buy
CCH0004485 1MG $721.88 Buy
CCH0004485 10MG $1732.5 Buy

10(S),17(S)-DiHDoHE Chemical Properties,Uses,Production

Description

Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities.1,2,3 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX).4 It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA.1,4 It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse.1 It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.4,5

Definition

ChEBI: (4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid is a dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13Z,15E,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10S,17S-stereoisomer). A natural isomer of protectin D1, one of the specialised proresolving mediators. It has a role as an anti-inflammatory agent and a human xenobiotic metabolite. It is a dihydroxydocosahexaenoic acid, a secondary allylic alcohol and a protectin.

References

1. Serhan, C.N., Gotlinger, K., Hong, S., et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes J. Immunol. 176(3),1848-1859(2006).
2. Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation Trends Immunol. 28(4),176-183(2007).
3. Schwab, J.M., Chiang, N., Arita, M., et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes Nature 447(7146),869-874(2007).
4. Chen, P., Fenet, B., Michaud, S., et al. Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation FEBS Lett. 583,3478-3484(2009).
5. Chen, P., Véricel, E., Lagarde, M., et al. Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation FASEB J. 25,382-388(2011).

10(S),17(S)-DiHDoHE Preparation Products And Raw materials

Raw materials

Preparation Products

10(S),17(S)-DiHDoHE Suppliers

Global( 27)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shanghai Universal Biotech Co.,Ltd 18768175414 gaojun@univ-bio.com China 24998 58
amyjetsci 027-59626688 18771149750 sales@amyjet.com China 3004 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7984 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.com China 24246 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Shanghai Universal Biotech Co.,Ltd 58
amyjetsci 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
10(S),17(S)-DiHDoHE 10(S),17(S)-DiHDoHE Exclusive 10(S),17(S)-DiHDHA 4,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, (4Z,7Z,10S,11E,13Z,15E,17S,19Z)- 871826-47-0