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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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Product Name:10(S),17(S)-DiHDHA
CAS:871826-47-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:10(S),17(S)-DiHDHA
CAS:871826-47-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
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Product Name:10(S),17(S)-DiHDoHE
CAS:871826-47-0
Purity:98% Package:25ug (solution); 100ug (solution); 500ug (solution); 50ug (solution) Remarks:Medbio
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Shanghai Universal Biotech Co.,Ltd
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18768175414 |
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gaojun@univ-bio.com |
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Product Name:10(S),17(S)-DiHDHA
CAS:871826-47-0
Package:25ug,100ug Remarks: 见优宁维官网
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| Company Name: |
amyjetsci
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027-59626688 18771149750 |
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| Products Intro: |
Product Name:10(S),17(S)-DiHDHA
Package:15ml/
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| | 10(S),17(S)-DiHDoHE Basic information |
| Product Name: | 10(S),17(S)-DiHDoHE | | Synonyms: | 10(S),17(S)-DiHDoHE;10(S),17(S)-DiHDoHE Exclusive;10(S),17(S)-DiHDHA;4,7,11,13,15,19-Docosahexaenoic acid, 10,17-dihydroxy-, (4Z,7Z,10S,11E,13Z,15E,17S,19Z)- | | CAS: | 871826-47-0 | | MF: | C22H32O4 | | MW: | 360.487 | | EINECS: | | | Product Categories: | | | Mol File: | 871826-47-0.mol |  |
| | 10(S),17(S)-DiHDoHE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 1 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.5 mg/ml | | form | Solid | | color | White to off-white |
| | 10(S),17(S)-DiHDoHE Usage And Synthesis |
| Description | Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities.1,2,3 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX).4 It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA.1,4 It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse.1 It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.4,5 | | Definition | ChEBI: (4Z,7Z,10S,11E,13Z,15E,17S,19Z)-10,17-dihydroxydocosahexaenoic acid is a dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13Z,15E,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10S,17S-stereoisomer). A natural isomer of protectin D1, one of the specialised proresolving mediators. It has a role as an anti-inflammatory agent and a human xenobiotic metabolite. It is a dihydroxydocosahexaenoic acid, a secondary allylic alcohol and a protectin. | | References | 1. Serhan, C.N., Gotlinger, K., Hong, S., et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes J. Immunol. 176(3),1848-1859(2006).
2. Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation Trends Immunol. 28(4),176-183(2007).
3. Schwab, J.M., Chiang, N., Arita, M., et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes Nature 447(7146),869-874(2007).
4. Chen, P., Fenet, B., Michaud, S., et al. Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation FEBS Lett. 583,3478-3484(2009).
5. Chen, P., Véricel, E., Lagarde, M., et al. Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation FASEB J. 25,382-388(2011). |
| | 10(S),17(S)-DiHDoHE Preparation Products And Raw materials |
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