1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide
- CAS No.
- Chemical Name:
- 1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide
- Synonyms
- ENMD 547-d8;6-AMino-1-[4-(3-Methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone-d8 HydrobroMide;1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide
- CBNumber:
- CB92622643
- Molecular Formula:
- C15H22BrD8N3O2
- Molecular Weight:
- 372.370894224
- MDL Number:
- MOL File:
- Mol file
1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide Chemical Properties,Uses,Production
Uses
1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 Monohydrobromide: Labelled ENMD 547, a selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a so luble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthr itis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.
1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 8)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Supplier | Advantage |
|---|---|
| Chemsky (shanghai) International Co.,Ltd | 60 |
1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide
6-AMino-1-[4-(3-Methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone-d8 HydrobroMide
ENMD 547-d8