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Bexagliflozin

Bexagliflozin Structure
Bexagliflozin structure
CAS No.
1118567-05-7
Chemical Name:
Bexagliflozin
Synonyms
CS-250;CS-2165;EGT1442;THR1442;THR 1442;THR-1442;EGT0001442;EGT-0001442;EGT 0001442;Bexgliflozin
CBNumber:
CB92650633
Molecular Formula:
C24H29ClO7
Molecular Weight:
464.94
MDL Number:
MFCD28100944
MOL File:
1118567-05-7.mol
MSDS File:
SDS
Last updated:2024-06-26 11:14:52
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Bexagliflozin Properties

Boiling point 671.0±55.0 °C(Predicted)
Density 1.41
storage temp. Store at -20°C
solubility DMSO:100.0(Max Conc. mg/mL);215.08(Max Conc. mM)
form A crystalline solid
pka 13.23±0.70(Predicted)
InChIKey BTCRKOKVYTVOLU-IZSIRFNDNA-N
SMILES [C@H]1(C2C=C(CC3C=CC(OCCOC4CC4)=CC=3)C(Cl)=CC=2)[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:0,22,24,26,28,r|
FDA UNII EY00JF42FV

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

Bexagliflozin price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21359 EGT-1442 ≥95% 1118567-05-7 1mg $32 2024-03-01 Buy
Cayman Chemical 21359 EGT-1442 ≥95% 1118567-05-7 5mg $139 2024-03-01 Buy
Cayman Chemical 21359 EGT-1442 ≥95% 1118567-05-7 10mg $243 2024-03-01 Buy
Cayman Chemical 21359 EGT-1442 ≥95% 1118567-05-7 25mg $533 2024-03-01 Buy
TRC B336785 Bexagliflozin3 1118567-05-7 10mg $310 2021-12-16 Buy
Product number Packaging Price Buy
21359 1mg $32 Buy
21359 5mg $139 Buy
21359 10mg $243 Buy
21359 25mg $533 Buy
B336785 10mg $310 Buy

Bexagliflozin Chemical Properties,Uses,Production

Description

EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively. It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.

Uses

Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients.

Definition

ChEBI: Bexagliflozin is a C-glycosyl comprising of beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl group. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a sodium-glucose transport protein subtype 2 inhibitor, a hypoglycemic agent and an antihypertensive agent. It is a C-glycosyl compound, an aromatic ether, a member of monochlorobenzenes, a diether and a member of cyclopropanes.

Mechanism of action

Bexagliflozin is a highly selective inhibitor of sodium-glucose cotransporter protein 2 (SGLT2), which cotransports sodium and glucose from the filtrate to the epithelium of the proximal renal tubule, thereby lowering the tubular glucose reabsorption threshold, reducing renal glucose reabsorption, and increasing urinary glucose excretion without affecting insulin levels.

Bexagliflozin synthesis

1459754-30-3
1118567-05-7
Synthesis of Bexagliflozin from (3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Bexagliflozin Preparation Products And Raw materials

Raw materials

2-Cyclopropoxyethyl4-methylbenzenesulfonate 2-(2-Bromoethyl)-1,3-dioxolane (3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate 4-broMo-1-chloro-2-(4-(2-cyclopropoxyethoxy)benzyl)benzene
5-bromo-2-chloro-4’-ethoxydiphenylmethane 4-(5-broMo-2-chlorobenzyl)phenol 5-Bromo-2-chlorobenzoic acid D-(+)-Glucono-1,5-lactone

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Preparation Products

Bexagliflozin Suppliers

Global( 106)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5224 58
Jinan Million Pharmaceutical Co., Ltd 		0531-68659554 +8613031714605 info@millionpharm.com China 200 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29894 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 19343 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39916 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 13214 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10522 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Supplier Advantage
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Jinan Million Pharmaceutical Co., Ltd 		58
career henan chemical co 		58
Accela ChemBio Inc. 		58
Chongqing Chemdad Co., Ltd 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58

View Lastest Price from Bexagliflozin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bexagliflozin pictures 2024-08-23 Bexagliflozin
1118567-05-7
 US $2.00 / kg 0.10000000149011612kg 99% 200KG Jinan Million Pharmaceutical Co., Ltd
Bexagliflozin pictures 2024-02-23 Bexagliflozin
1118567-05-7
 US $380.00 / g 1g 99 50 Kg R&D Scientific Inc.
EGT1442 pictures 2019-07-06 EGT1442
1118567-05-7
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • Bexagliflozin pictures
  • Bexagliflozin
    1118567-05-7
  • US $2.00 / kg
  • 99%
  • Jinan Million Pharmaceutical Co., Ltd
  • EGT1442 pictures
  • EGT1442
    1118567-05-7
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co
EGT1442 (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol Bexagliflozin EGT1442(Bexagliflozin,THR1442) Bexagliflozin，EGT1442 CS-2165 EGT 0001442 EGT0001442 EGT-0001442 EGT1442; THR1442; EGT0001442; EGT-1442; THR-1442; EGT-0001442; EGT 1442; THR 1442; EGT 0001442 THR 1442 THR1442 THR-1442 CS-250 Bexagliflozin(THR1442,EGT1442)| BEXAGLIFLOZIN;EGT-1442;THR1442;EGT0001442;EGT-1442;THR-1442;EGT-0001442;EGT 1442;THR 1442;EGT 0001442 Bexagliflozin (THR1442) D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)- Bexagliflozin3 Bexgliflozin (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Bexagliflozin Impurity 1 Bexgliflozin Impurity 1 Bexgliflozin (EGT1442) 1118567-05-7