Rubitecan
- CAS No.
- 91421-42-0
- Chemical Name:
- Rubitecan
- Synonyms
- 9-NC;RFS 2000;Oratheci;orathecin;RUBITECAN;RUBETICAN;Rubitecane;9-NITRO-CPT;9-Nitrocamptothecin;Rubitecan USP/EP/BP
- CBNumber:
- CB9270138
- Molecular Formula:
- C20H15N3O6
- Molecular Weight:
- 393.35
- MDL Number:
- MFCD06656294
- MOL File:
- 91421-42-0.mol
- MSDS File:
- SDS
| Melting point | 182-186°C |
|---|---|
| alpha | D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4) |
| Boiling point | 816.3±65.0 °C(Predicted) |
| Density | 1.63 |
| Flash point | 106℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Chloroform, Methanol |
| form | Solid |
| pka | 11.16±0.20(Predicted) |
| color | Yellow |
| Merck | 14,8288 |
| CAS DataBase Reference | 91421-42-0(CAS DataBase Reference) |
| FDA UNII | H19C446XXB |
| NCI Drug Dictionary | Orathecin |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | UQ0493300 |
| HS Code | 29399990 |
Rubitecan price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R3655 | Rubitecan | 91421-42-0 | 10mg | $56.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | R3655 | Rubitecan | 91421-42-0 | 50mg | $225 | 2024-03-01 | Buy |
| TCI Chemical | N0822 | 9-Nitrocamptothecin >98.0%(HPLC) | 91421-42-0 | 100mg | $273 | 2024-03-01 | Buy |
| Cayman Chemical | 28956 | Rubitecan | 91421-42-0 | 10mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 28956 | Rubitecan | 91421-42-0 | 25mg | $112 | 2024-03-01 | Buy |
Rubitecan Chemical Properties,Uses,Production
Description
Rubitecan, marketed by Supergen as Orathecin, is a promising oral treatment for solid melanoma, prostate, breast, ovarian, and other cancers, as well as leukemia. It is a derivative of camptothecin, a topoisomerase inhibitor known from Chinese Traditional Medicine. It selectively targets the critical S-stage of cellular reproduction – particularly in acidic environments, as in many cancer cells – relaxing DNA supercoiling and generating lethal breaks in the DNA. Due to insolubility, its biological delivery mechanism is not yet effective, and it has not been approved for clinical use.
Reference
https://www.sciencedirect.com/topics/medicine-and-dentistry/rubitecan
https://en.wikipedia.org/wiki/Rubitecan
https://en.wikipedia.org/wiki/Topoisomerase_inhibitor
https://en.wikipedia.org/wiki/Camptothecin#cite_note-Y.Pommier_2003-14
https://www.ncbi.nlm.nih.gov/pubmed/1995300
Description
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.
Chemical Properties
Yellow Amorphous Powder
Uses
Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.
Definition
ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Rubitecan Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10310 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
View Lastest Price from Rubitecan manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-10-14 | Rubitecan
91421-42-0
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-07-03 | Rubitecan USP/EP/BP
91421-42-0
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-03 | Rubitecan
91421-42-0
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd |
-
- Rubitecan
91421-42-0
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Rubitecan USP/EP/BP
91421-42-0
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Rubitecan
91421-42-0
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd