Quetiapine fumarate
- CAS No.
- 111974-72-2
- Chemical Name:
- Quetiapine fumarate
- Synonyms
- SEROQUEL;QUETIAPINE HEMIFUMARATE;Quetiapine heMifuMarate salt;ICI-204636;Quetine fumarate;QuetiapineFamarate;QUETIAPINE FUMARATE;Quitiapine Fumarate;Quetinapine Fumarate;Quintiapine fumarate
- CBNumber:
- CB9270451
- Molecular Formula:
- C25H29N3O6S
- Molecular Weight:
- 499.58
- MDL Number:
- MFCD03423782
- MOL File:
- 111974-72-2.mol
- MSDS File:
- SDS
| Melting point | 174-176°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| form | powder |
| color | white to off-white |
| Merck | 14,8039 |
| BCS Class | 2 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 111974-72-2(CAS DataBase Reference) |
| FDA UNII | 2S3PL1B6UJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P273-P301+P312+P330 | |||||||||
| Hazard Codes | Xn,N,T,F | |||||||||
| Risk Statements | 22-50/53-52/53-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 60-61-45-36/37-16 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KK3605000 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
Quetiapine fumarate price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Q-001 | Quetiapine fumarate solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 111974-72-2 | 1mL | $110 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1856 | Quetiapine fumarate Pharmaceutical Secondary Standard; Certified Reference Material | 111974-72-2 | 1g | $214 | 2024-03-01 | Buy |
| TCI Chemical | Q0092 | Quetiapine Hemifumarate >98.0%(HPLC)(T) | 111974-72-2 | 5g | $196 | 2024-03-01 | Buy |
| TCI Chemical | Q0092 | Quetiapine Hemifumarate >98.0%(HPLC)(T) | 111974-72-2 | 25g | $664 | 2024-03-01 | Buy |
| Cayman Chemical | 14152 | Quetiapine (hemifumarate) ≥95% | 111974-72-2 | 1g | $32 | 2024-03-01 | Buy |
Quetiapine fumarate Chemical Properties,Uses,Production
Antipsychotics
Quetiapine fumarate is an antipsychotic, successfully developed by the AstraZeneca United States, it interacts with a variety of neurotransmitter receptors, in the brain, it displays high degree affinity for serotonin (5-HT2) receptor, and it is greater than dopamine D1 and D2 dopamine receptor affinity in the brain. Quetiapine also has high affinity for histamine H1 receptor and adrenergic α1 receptors, and low affinity for α2 receptors, but it basically displays no affinity for cholinergic muscarinic receptors or benzodiazepine receptors . It shows positive results in antipsychotic activity assays such as conditioned avoidance reflex . In clinical, it is mainly used in treatment for adults with severe depression, acute manic episodes of bipolar disorder and schizophrenia of different types . It is not only effective for the positive symptoms of schizophrenia, but also having a certain effect for negative symptoms . It can also alleviate affective symptoms associated with schizophrenia, such as depression, anxiety symptoms and cognitive deficits.
The above information is edited by the chemicalbook of Tian Ye.
Chemical properties
White crystalline powder.
Uses
A non-classical antipsychotics.
Description
Quetiapine hemifumarate (111974-72-2) is an atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively.2 Reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation in a rat model.3 Efficacious as a monotherapy in the treatment of posttraumatic stress disorder.4
Chemical Properties
White Crystalline Solid
Uses
Quetiapine hemifumarate salt has been used as an antagonist for β-arrestin 2 mutant T205M recruitment.
Uses
Used as an antipsychotic. Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties
Uses
antihypertensive adrenergic receptor blocking agent with selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.
brand name
Seroquel (AstraZeneca).
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Hazard
Human systemic effects.
Biochem/physiol Actions
Quetiapine hemifumarate is an atypical antipsychotic, a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.
in vitro
quetiapine has shown affinity for various neurotransmitter receptorsincluding dopamine, serotonin, histamine, and adrenergicreceptors, quetiapine exihibited binding characteristics at the dopamine-2receptorsimilar to those of clozapine [1].
in vivo
in animal models, quetiapine exihibited a preclinical profile suggestive of antipsychotic activity with a reduced tendency to cause extrapyramidal symptoms (eps) and sustained prolactin elevation. quetiapine altered neurotensin neurotransmission and c-fos expression in limbic but not motor brain regions.in humans, quetiapine exhibited linear pharmacokinetics with a mean terminal half-life of 7 hours.the optimal dosing range for quetiapine was 150 to 750 mg/day, and recent results suggested that once-daily dosing might be suitable for some patients [1].quetiapine prevented schizophrenia and depression in hippocampal cell proliferation and bdnf expression caused by chronic restraint stress (crs) in rats in a dose-dependent manner. quetiapine (5 mg/kg) in combination with venlafaxine (2.5 mg/kg) increaseed hippocampal cell proliferation and prevented bdnf decrease in stressed rats, while each of the drugs exerted mild or no effects [2].in rats subjected to chronic-restraint stress, chronic administration of quetiapine attenuated the decrease in levels of brain-derived neurotrophic factor (bdnf) in the hippocampi. the stress-induced suppression of hippocampal neurogenesis was reversed after post-stress administration of quetiapine (10 mg/kg) for 7 or 21 days, evidenced in the numbers of pcreb-positive and brdu-labeled cells that were comparable to those in non-stressed rats but higher than those in the vehicle-treated rats [3].
target
Androgen Receptor | Estrogen receptor | Progestogen receptor
storage
+4°C
References
1) Ellenbroek et al. (1996); Activity of “seroquel” (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with clozapine; Neuropsychopharmacology 15 406 2) Saller and Salama (1993), Seroquel: biochemical profile of a potential atypical antipsychotic; Psychopharmacolgy (Berl) 112 285 3) Ignacio et al. (2017), Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation; Behav. Brain Res. 320 225 4) Villarreal et al. (2016), Efficacy of Quetiapine Monotherapy in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial; Am. J. Psychiatry 173 1205
Quetiapine fumarate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9314 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3096 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 148 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Xuchang Hengsheng Pharmaceutical Co., Ltd | +86-03745692999 +86-13569491380 | xccxn@xchsyy.com | China | 15 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
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- Oct 10，2024
View Lastest Price from Quetiapine fumarate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-25 | Quetiapine fumarate
111974-72-2
|
US $0.00 / Kg/Bag | 2Kg/Bag | EP | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-11-25 | Quetiapine fumarate
111974-72-2
|
US $10.00 / ASSAYS | 1ASSAYS | 99% | 10 ton | Dorne Chemical Technology co. LTD | |
 |
2024-11-20 | Quetiapine fumarate
111974-72-2
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd |
-
- Quetiapine fumarate
111974-72-2
- US $0.00 / Kg/Bag
- EP
- Sinoway Industrial co., ltd.
-
- Quetiapine fumarate
111974-72-2
- US $10.00 / ASSAYS
- 99%
- Dorne Chemical Technology co. LTD
-
- Quetiapine fumarate
111974-72-2
- US $10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
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