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DDR1-IN-1

CAS No.
1449685-96-4
Chemical Name:
DDR1-IN-1
Synonyms
TL4-44;CS-1427;DDR-IN-1;DDR1-IN-1;DDR1 inhibitor 1;Discoidin Domain Receptor,inhibit,Ddr-1-In-1,Inhibitor,Ddr1 In 1,Ddr1In1;4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide;4-[(4-ethylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide;N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide;Benzamide, N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-
CBNumber:
CB92705081
Molecular Formula:
C30H31F3N4O3
Molecular Weight:
552.59
MDL Number:
MFCD28144507
MOL File:
1449685-96-4.mol
Last updated:2024-10-31 21:04:56

DDR1-IN-1 Properties

storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (180.97 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form Powder
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H413
Precautionary statements  P264-P270-P301+P312-P330-P501

DDR1-IN-1 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2274 DDR1-IN-1 ≥98% (HPLC) 1449685-96-4 5mg $118 2024-03-01 Buy
Sigma-Aldrich SML2274 DDR1-IN-1 ≥98% (HPLC) 1449685-96-4 25mg $399 2024-03-01 Buy
ChemScene CS-2808 DDR1-IN-1 98.20% 1449685-96-4 5mg $90 2021-12-16 Buy
ChemScene CS-2808 DDR1-IN-1 98.20% 1449685-96-4 10mg $140 2021-12-16 Buy
Biosynth Carbosynth BD165965 DDR1-IN-1 dihydrochloride 1449685-96-4 10mg $145 2021-12-16 Buy
Product number Packaging Price Buy
SML2274 5mg $118 Buy
SML2274 25mg $399 Buy
CS-2808 5mg $90 Buy
CS-2808 10mg $140 Buy
BD165965 10mg $145 Buy

DDR1-IN-1 Chemical Properties,Uses,Production

Definition

ChEBI: DDR1-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 5-(5-amino-2-methylphenoxy)-1,3-dihydro-2H-indol-2-one. It is a potent inhibitor of discoidin domain receptor tyrosine kinase 1 and 2 (DDR1/2) with IC50 = 105 nM and 413 nM, respectively. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a N-alkylpiperazine, a member of benzamides, a member of (trifluoromethyl)benzenes, a secondary carboxamide, an aromatic ether and a member of oxindoles.

Biochem/physiol Actions

DDR1-IN-1 is a type II, subtype-selective discoidin domain receptor (DDR) tyrosine kinase inhibitor (DDR1/2 IC50 = 105 nM/413 nM) that effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture (123%, 70%, 50% of control, respectively, post 48-hr 250 nM DDR1-IN-1, 82.5 nM GSK2126458, or combined treatment). ent). ned treatment).

DDR1-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32038 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38463 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Aceschem Inc.
+1-817863-6948 +1-(817)863-6948 sales@aceschem.com United States 19632 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from DDR1-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ddr1-In-1 pictures 2024-10-31 Ddr1-In-1
1449685-96-4
US $34.00-77.00 / mg 99.84% 10g TargetMol Chemicals Inc.
DDR1-IN-1 pictures 2019-12-27 DDR1-IN-1
1449685-96-4
US $1.00 / KG 1KG 97%-99.9% 100kg Career Henan Chemical Co
  • Ddr1-In-1 pictures
  • Ddr1-In-1
    1449685-96-4
  • US $34.00-77.00 / mg
  • 99.84%
  • TargetMol Chemicals Inc.
  • DDR1-IN-1 pictures
  • DDR1-IN-1
    1449685-96-4
  • US $1.00 / KG
  • 97%-99.9%
  • Career Henan Chemical Co

DDR1-IN-1 Spectrum

TL4-44 DDR-IN-1 DDR1-IN-1 N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide 4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide CS-1427 DDR1 inhibitor 1 Benzamide, N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)- Discoidin Domain Receptor,inhibit,Ddr-1-In-1,Inhibitor,Ddr1 In 1,Ddr1In1 4-[(4-ethylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide 1449685-96-4 C30H31F3N4O3