HLM006474
- CAS No.
- 353519-63-8
- Chemical Name:
- HLM006474
- Synonyms
- CS-1224;HLM006474;E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem;HLM006474,inhibit,HLM 006474,Early 2 Factor (E2F),Inhibitor,HLM-006474;7-((4-Ethoxy-3-methylphenyl)(pyridin-2-ylamino)methyl)-2-methylquinolin-8-ol;8-Quinolinol, 7-[(4-ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-;7- (4-ethoxy-3-methylphenyl) (pyridine-2-ylamino) methyl) -2-methylquinoline-8-ol
- CBNumber:
- CB92715640
- Molecular Formula:
- C25H25N3O2
- Molecular Weight:
- 399.48
- MDL Number:
- MFCD02168344
- MOL File:
- 353519-63-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H413 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| NFPA 704 |
|
HLM006474 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1260 | HLM006474 ≥98% (HPLC) | 353519-63-8 | 5MG | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1260 | HLM006474 ≥98% (HPLC) | 353519-63-8 | 25MG | $462 | 2024-03-01 | Buy |
| Sigma-Aldrich | 324461 | E2F Inhibitor, HLM006474 - CAS 353519-63-8 - Calbiochem The E2F Inhibitor, HLM006474, also referenced under CAS 353519-63-8, controls the biological activity of E2F. This small molecule/inhibitor is primarily used for Cancer applications. |
353519-63-8 | 10mg | $182 | 2024-03-01 | Buy |
| Cayman Chemical | 28276 | HLM006474 | 353519-63-8 | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 28276 | HLM006474 | 353519-63-8 | 10mg | $121 | 2024-03-01 | Buy |
HLM006474 Chemical Properties,Uses,Production
Description
HLM006474 is a non-selective inhibitor of the transcription factor E2F (IC50 = 29.8 μM for E2F4). It inhibits DNA binding to E2F1, E2F2, and E2F4 in A375 melanoma cells when used at a concentration of 40 μM. HLM006474 (40 μM) decreases protein levels of E2F4 and cyclin D3 and induces apoptosis in A375 cells. It also induces apoptosis in MDA-MB-231, but not MCF-7, cells and inhibits the growth of cancer cells in a panel of 17 lung cancer cell lines (IC50s = 15.5-75.1 μM). HLM006474 reduces tumor growth in retinoblastoma-prone Chx10Cre;Rbfl/fl;p107-/- mice and in an A375 mouse xenograft model when administered at a dose of 100 mg/kg and 2 mg per mouse, respectively.
Uses
HLM 006474 acts as an E2F transcription factor inhibitor, preventing DNA binding activity. This results in the induction of apoptosis in breast cancer cells.
Uses
HLM006474 has been used as an E2 factor?(E2F) inhibitor in human nasopharyngeal carcinoma hone-1 cells and T. annulata-infected TBL20 cells.
General Description
A cell-permeable 8-hydroxyquinoline compound that is reported to inhibit nuclear E2F complexes DNA binding activity (IC50 = 30 μM) and downregulate E2F expression in the melanoma cell line A375, resulting in eventual apoptosis induction without upregulating p53 expression as commonly seen with traditional chemotherapeutic agents, such as Cisplatin (Cat. No. 232120), doxorubicin (Cat. No. 324380), and VP-16 (Cat. No. 341205).
Biochem/physiol Actions
HLM006474 is a pan-E2F transcription factor inhibitor. E2F s part of the CDK/Rb/E2F pathway. When phosphorylated by CDKs, the tumor suppressor retinoblastoma protein (Rb) is inactivated, releasing E2Fs and allowing cell cycle progression. HLM006474 inhibited DNA-binding of all E2F complexes and down-regulated expression of E2F4 protein. HLM006474 induced apoptosis of A375 melanoma cells and synergized with paclitaxel in lung cancer cell lines.
HLM006474 Preparation Products And Raw materials
Raw materials
Preparation Products
HLM006474 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4573 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 |